Protein Alignment Kif3C and KIF11

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 225/706 - (31%)
• Similarity: 333/706 - (47%)
• Gaps: 125/706 - (17%)

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEF--AVSV-TNPSARISQQKKFIFDSVYNMKTDTEVI 64
            :||:|||||||.|..|::.:..:|||.:..  .||| |...|..|.:|.:.||.|:...|....:
Human    17 KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDV 81

  Fly    65 YDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNS--------TGIIPKCFDHIFER 121
            |..:...:::..|.|||.|||||||||.|||.||:|:.:.:..        .||||:....|||:
Human    82 YRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEK 146

  Fly   122 ISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNV-INHFLKELPGIGVSVPTLTTQPVVNANQC 185
            :: .....:...|:.||||||.:.||||.:.:.:. :..|.......||.:..|....|.|.::.
Human   147 LT-DNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEV 210

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSER 250
            |..|..|...|.|||||||..|||||::|::|:....  .:|..:....|  |||:||||||||.
Human   211 YQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKE--TTIDGEELVKI--GKLNLVDLAGSEN 271

  Fly   251 QRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISC 315
            ..::||...|.:||..||.||..||.||::||: :..|||:|:|||||:|||||||.|:|.:|:.
Human   272 IGRSGAVDKRAREAGNINQSLLTLGRVITALVE-RTPHVPYRESKLTRILQDSLGGRTRTSIIAT 335

  Fly   316 ISPTDIHYDETISTLRYASRAKNISNKPKINED-PKDARLRQYQNEILYLKRMLQESQQIINKN- 378
            |||..::.:||:|||.||.|||||.|||::|:. .|.|.:::|..||..|||.|..:::   ||
Human   336 ISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAARE---KNG 397

  Fly   379 ---NDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKA----------SFKTNNSILTKPNFPL 430
               ::.|..:.|....:|..        ||::|.....|          .|..|.:.|.:....|
Human   398 VYISEENFRVMSGKLTVQEE--------QIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDL 454

  Fly   431 IQSKEEVQLQAR----SRIDLIKRSLIGG------ERIHDFELKEKHMARKYAAQRHLSAIAIAL 485
            ....:|::...:    :::.|:|...|..      |::||...|..:...:  ..:.:|.:...|
Human   455 QNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEE--TTKDVSGLHSKL 517

  Fly   486 SRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLG 550
            .|.|..|:     |.|. .|:|..||                   |||.|....|...|......
Human   518 DRKKAVDQ-----HNAE-AQDIFGKN-------------------LNSLFNNMEELIKDGSSKQK 557

  Fly   551 RQVKFHQQLFLK-FSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPES----------------- 597
            ..::.|:.||.. .||:....|   |..|:...||.:       |||:
Human   558 AMLEVHKTLFGNLLSSSVSALD---TITTVALGSLTS-------IPENVSTHVSQIFNMILKEQS 612

  Fly   598 ----------DLIKLPPATQKSGLHCI-HPLV-----IHSENQHNNQNEIVVGEKV 637
                      :||.:......|.|..| .|.|     |:|:.:|..:..:.|.:|:
Human   613 LAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKI 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	147/347 (42%)
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	153/356 (43%)
		PRK12704	350..>508	CDD:237177	42/170 (25%)
		YhaN	380..>761	CDD:443752	69/337 (20%)
		Microtub_bind	916..1053	CDD:464048