Protein Alignment Kif3C and KIF5B

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_004512.1
• Gene: KIF5B / 3799
• HGNCID: 6324
• Length: 963
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 223/759 - (29%)
• Similarity: 335/759 - (44%)
• Gaps: 200/759 - (26%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEI-NEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            ||||:.|.||:|::|..|..:.|.:. .|..|.:.:        |.:.||.|:...|..|.:|::
Human     8 NIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIAS--------KPYAFDRVFQSSTSQEQVYND 64

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI-SMTTNVRYL 131
            ....:|:..:|||||||||||||..||||||:|..:.....||||:....||..| ||..|:.:.
Human    65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFH 129

  Fly   132 ALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNKNR 196
            ..|:|.|||.::|||||:.::....::.....:|    .|...|.:.|.:.::..|.:..|..||
Human   130 IKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVP----YVKGCTERFVCSPDEVMDTIDEGKSNR 190

  Fly   197 VTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRL 261
            ..|.|.||::|||||:||.|.::|.   |:.......    |||.||||||||:..||||:|..|
Human   191 HVAVTNMNEHSSRSHSIFLINVKQE---NTQTEQKLS----GKLYLVDLAGSEKVSKTGAEGAVL 248

  Fly   262 KEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDET 326
            .||..||.||||||||||:|.:| :.:||:||||:||:||||||||.:|.::.|.||:..:..||
Human   249 DEAKNINKSLSALGNVISALAEG-STYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESET 312

  Fly   327 ISTLRYASRAKNISN----------------------KPKI------------------------ 345
            .|||.:..|||.|.|                      |.||
Human   313 KSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPID 377

  Fly   346 ----------------------NEDP----------KDARLRQYQNEILYLKRMLQESQQIINKN 378
                                  |:.|          .||..|:.:.||..|.:.|.:..:.||:.
Human   378 EQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQ 442

  Fly   379 NDPNKIIKSPLKIIQHTNMNSTK----NVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQ- 438
            :...:.:|:.: :.|...:.||:    |:| .:|.|     .:..|.          .|||||:
Human   443 SQLVEKLKTQM-LDQEELLASTRRDQDNMQ-AELNR-----LQAEND----------ASKEEVKE 490

  Fly   439 -LQARSR--IDLIKRSLIGGERIHDFEL--------------------KEKHMA---RKYAAQ-- 475
             |||...  ::..::|....::..::||                    |.|.|.   :|.||:
Human   491 VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMM 555

  Fly   476 ----RHLSAIAIALSRVKCEDRDLLQGH-YATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNS-- 533
                :.|:.|.||:.     :.|:.|.. ...|.:|..:...||.|.|.::|.:......|.|
Human   556 ASLLKDLAEIGIAVG-----NNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQ 615

  Fly   534 -EFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPES 597
             |.....|:...|:.....::..|:   .|..|              |...|.|.:.|..::.||
Human   616 TESNKKMEENEKELAACQLRISQHE---AKIKS--------------LTEYLQNVEQKKRQLEES 663

  Fly   598 ------DLIKLPPATQKSGLHCIHPLVIHSENQHNNQ----NEI 631
                  :|::| .|.:|     :|.:    |.:|.|:    ||:
Human   664 VDALSEELVQL-RAQEK-----VHEM----EKEHLNKVQTANEV 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	144/336 (43%)
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	144/336 (43%)
		SMC_prok_B	<414..803	CDD:274008	72/333 (22%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963