Protein Alignment Kif3C and unc-104

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 216/750 - (28%)
• Similarity: 327/750 - (43%)
• Gaps: 190/750 - (25%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSA---RISQQKKFIFDSVY--------NM 57
            ::||.||.||.|..|..|..:.|:|:.....::|||..   .....|:|.||..|        :.
  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADF 67

  Fly    58 KTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI 122
            .|.: ::|.::...:::.:.:|||..||||||||.||::||.|.:. ....||||.....:|.||
  Fly    68 STQS-MVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQE-EQQEGIIPMICKDLFTRI 130

  Fly   123 --SMTTNVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQ 184
              :.|.:::|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:...
  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTDYQD 191

  Fly   185 CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTI--TLEQSPFLNSIGSDAFGGICRGKLSLVDLAG 247
            .:|.:..|||.|..|||.||:.|||||.:|||  |..:...:.::.::..     .|:|||||||
  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKV-----SKISLVDLAG 251

  Fly   248 SERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--------GKAKHVPFRDSKLTRLLQDSL 304
            |||...|||:|.||||.:.||.||:.||.|||:|.:        .||..:|:|||.||.||:::|
  Fly   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENL 316

  Fly   305 GGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML- 368
            |||:||.||:.|||.||:||||:||||||.|||.|..|..:|||.....:|:.:.||..|:.:|
  Fly   317 GGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLK 381

  Fly   369 ------QESQQ------------------------------------------------------ 373
                  ||..:
  Fly   382 AEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRV 446

  Fly   374 ------------------------------IINKNNDPN------KIIKSPLKIIQHTNMNSTKN 402
                                          ::|.|.|||      ..||..|..:.....|..::
  Fly   447 QREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQD 511

  Fly   403 VQIID---LGRNCKASFKTNNSILT----KPNFPLIQSKEEVQ---LQARSRIDLIKRSLIGGER 457
            :|:..   |..:|  :|:..||.:|    |.....:..::.|:   |:..||:.|.|.
  Fly   512 IQLSGSHILKEHC--TFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKN------- 567

  Fly   458 IHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATI----TQEIDIKNDYIRKCK 518
             |.|.......||:  .:..:.....|.:.|:..|...:..::|..    .|.||:|.:..::..
  Fly   568 -HVFRFTNPEQARE--LRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLD 629

  Fly   519 EKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSS--------------NPGK 569
            ...:..:.|....:.:|:..|:.|...|..|.:||:........:||              || .
  Fly   630 NLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNP-M 693

  Fly   570 FDRNWTPD-----------------TILQNSLWND 587
            ::..||..                 |.|::.||.:
  Fly   694 YESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGN 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	151/358 (42%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	153/365 (42%)
		Kinesin_assoc	355..498	CDD:465047	17/142 (12%)
		FHA_KIF1	474..574	CDD:438757	25/109 (23%)
		YhaN	<575..>666	CDD:443752	18/92 (20%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939