DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif1a

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_038940678.1	Gene:	Kif1a / 363288	RGDID:	1304996	Length:	1800	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	219/755 - (29%)
Similarity:	330/755 - (43%)	Gaps:	192/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE------ 62
            ::||.||.||.|..|..|:.:.|::::....::.||.......|.|.||..|...|..|
  Rat     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYAS 69

  Fly    63 --VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125
              .:|.::...:::...||||..||||||||.||::||.|.:. .:..||||:..:.:|.||:.|
  Rat    70 QKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQE-KDQQGIIPQLCEDLFSRINDT 133

  Fly   126 T--NVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYD 187
            |  |:.|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:.|...|
  Rat   134 TNDNMSYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTSYNDIQD 194

  Fly   188 WLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICR---GKLSLVDLAGSE 249
            .:..|||.|..|||.||:.|||||.:|.|...|.      ..||...|..   .|:|||||||||
  Rat   195 LMDSGNKARTVAATNMNETSSRSHAVFNIIFTQK------RHDAETNITTEKVSKISLVDLAGSE 253

  Fly   250 RQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----------GKAKHVPFRDSKLTRLLQDS 303
            |...|||:|.||||.:.||.||:.||.|||:|.:           .|...:|:|||.||.||:::
  Rat   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLREN 318

  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368
            ||||::|.|::.:||.||:||||:||||||.|||.|.....|||||.:..:|:.::|:..|:.:|
  Rat   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLL 383

  Fly   369 --QESQQIINKNNDP------NKII--------------------------------------KS 387
              |....|.:.|..|      |.::                                      |.
  Rat   384 YAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKE 448

  Fly   388 PLKIIQHTN------MNSTKNVQ------IIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQ 440
            ..|||...|      :..|:.::      :.::|...:....| ..:.:....|.:.:..|..|.
  Rat   449 TEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGT-LGVFSPKKTPHLVNLNEDPLM 512

  Fly   441 ARSRIDLIKRSL--IG---GERIHDFEL-----KEKHM---------------------ARKYAA 474
            :...:..||..:  :|   .||..|..|     ||:|.                     |..|..
  Rat   513 SECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVN 577

  Fly   475 QRHLSAIAIALS-------------------------RVKCED------------RDLLQGHYAT 502
            .:.::..:|..|                         |..|.:            |:||:.....
  Rat   578 GKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGID 642

  Fly   503 ITQEI-----DIKNDYIRKCKEKIKMLEMEVSDLNSEF-----QLD----------REDYLDEIR 547
            :.||:     ::::.|.|:.:|...:||.:..|..|:.     |:|          .|:..||::
  Rat   643 MKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQ 707

  Fly   548 NLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWND 587
            ...|:.:.....|.|:         .|...|.|::.||.:
  Rat   708 WTERECELALWAFRKW---------KWYQFTSLRDLLWGN 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	152/359 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	149/353 (42%)
Kif1a	XP_038940678.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	153/366 (42%)
		Kinesin_assoc	358..524	CDD:406567	27/166 (16%)
		FHA	501..605	CDD:238017	17/103 (17%)
		KIF1B	814..861	CDD:403579
		DUF3694	1250..1406	CDD:403614
		PH_KIFIA_KIFIB	1681..1783	CDD:269939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910