DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Cenpe

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_038959788.1	Gene:	Cenpe / 362044	RGDID:	1307115	Length:	2456	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	201/611 - (32%)
Similarity:	304/611 - (49%)	Gaps:	75/611 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEN--IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEV 63
            |:|.  :.|.||.||:|..|:|....:.:    :..:..|...:....|.|.||.|::....|:.
  Rat     1 MAEEAAVAVCVRVRPLNSREEELGEASHI----YWKTDKNAIYQSDGGKSFQFDRVFHSNETTKN 61

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128
            :|:|:...::.|.|:||||||||||||..||||||.|.|   :..|:||:....||:||......
  Rat    62 VYEEIAVPIISSAIQGYNGTIFAYGQTASGKTHTMMGSE---DCLGVIPRAIHDIFQRIKKFPER 123

  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193
            .:|..|:|:|||||.|.|||...:....:  .::|.....|.|..||.:.|..|.....||..|.
  Rat   124 EFLLRVSYMEIYNETITDLLCNTQKVKPL--IIREDINRNVYVADLTEEVVYTAEMALKWLATGE 186

  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQG 258
            |||....|.||:.||||||||.:.||......|...|  |.|....|:|||||||||..:|||:|
  Rat   187 KNRHYGITKMNQRSSRSHTIFRMILESREKAESSNCD--GSIKVSHLNLVDLAGSERAAQTGAEG 249

  Fly   259 DRLKEASQINLSLSALGNVISSLVDGK-AKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIH 322
            .||||...||.:|..||.||..|.||: ...:.:|||||||:||:|||||.||.:|..|:|..:
  Rat   250 MRLKEGCYINRNLLILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASL- 313

  Fly   323 YDETISTLRYASRAKNISNKPKINEDPKD-ARLRQYQNEILYLKRMLQESQQIINKNNDPNKIIK 386
             |||::||::||.||.:.|.|.:||...| |.|::|:.||:.||:.|:|    :|......:|.|
  Rat   314 -DETLTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRREIVDLKKQLEE----VNTKTRAQEIEK 373

  Fly   387 SPL-KIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKR 450
            ..| :::...::  .:.||...: :|.|....|::||..         ::|::::.:.|:.....
  Rat   374 DQLAQLLDEKDL--LQKVQDEKI-QNLKRMLVTSSSIAL---------QQELEIKKKRRVTWCFG 426

  Fly   451 SLIGGERIHDFELKEKHMAR----KYAAQRHLSAIAIALSRVKCED-------RDLLQGHYATIT 504
            .:.....:.:|::......|    .....|..|.:.:..|.:..|.       ..|.:..:::.|
  Rat   427 KMKDSNYVKEFKIPTNITTRTRKTSVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAEWSSAT 491

  Fly   505 QEIDIKN-----------------DY--IRKCKEKIKMLEMEVSDLNS-EFQLDRED------YL 543
            ..:..:|                 ||  :|:..|.:|:...|.::|.. ||...||:      .:
  Rat   492 ALLSEENLESELTSLNTQYNNLVLDYEQLRRENEDLKLKLKEKNELEEFEFLEQREEKDQELQLM 556

  Fly   544 DEIRNLGRQVK----FHQQLFLKFSS 565
            .|:.||...:|    ::|.|..:.||
  Rat   557 HEVSNLKNLIKHAEEYNQDLENELSS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	145/338 (43%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	142/329 (43%)
Cenpe	XP_038959788.1	KISc_CENP_E	6..329	CDD:276825	144/335 (43%)
		Smc	<334..1057	CDD:224117	53/265 (20%)
		Smc	787..1603	CDD:224117
		Smc	1320..2167	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910