DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif15

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_038937602.1	Gene:	Kif15 / 353302	RGDID:	727790	Length:	1396	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	239/731 - (32%)
Similarity:	348/731 - (47%)	Gaps:	133/731 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVRCRPMNQTEKERN-----CQNIVEINEFAVSV-TNPSARISQQKKFIFDSVYNMKTDTEV 63
            |||.||.||..:..:..:     |.::  :::.|:.: :||     ..|.|:||.|..|.|..|.
  Rat    27 IKVFVRIRPAEEGARSADGEQSLCLSV--LSQTALRLHSNP-----DPKTFVFDYVAGMDTTQES 84

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG---DENFS-NSTGIIPKCFDHIF----- 119
            ::..:..|:|||.:.|||||||||||||.|||.||.|   .:||| |..|:||:.|:::|
  Rat    85 VFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGVIPRSFEYLFSLIDR 149

  Fly   120 ERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQ 184
            |:........:|...:::|:|||:|.|||:...    :..:|:|....||.|.....|.|.:|.:
  Rat   150 EKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSAS----VGLYLREHIKKGVFVVGAVEQVVASAAE 210

  Fly   185 CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSE 249
            .|..|..|.:||..|:|.||:.|||||.:||||:|..    ...|:|. .|....|:||||||||
  Rat   211 AYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESM----EKSSEAV-NIRTSLLNLVDLAGSE 270

  Fly   250 RQRKTGAQGDRLKEASQINLSLSALGNVISSLVD---GKAKHVPFRDSKLTRLLQDSLGGNTKTL 311
            ||:.|.|:|.|||||..||.|||.||.||::|||   ||.:||.:||||||.||:||||||.||.
  Rat   271 RQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTA 335

  Fly   312 MISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQE--SQQI 374
            :|:.:.|....:.||:|||.:|.|||.|.||..:|||.: ..:.|.|.|:..|:..|.:  |.|:
  Rat   336 IIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLREQLSQFTSGQL 399

  Fly   375 I---------NKNNDPNKIIKSPL---KIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPN 427
            .         .|.|.....:::.|   |..|.......|..|:.||... |..|..:|.::.|..
  Rat   400 TPGSSLARDKEKANYMEYFLEAMLFFKKSEQEKKSLVEKITQLEDLTLK-KEKFIQSNKMIVKFR 463

  Fly   428 FPLIQSKEEVQLQARSRI-----DLIKRSLIGGERIHDFELKEKHMAR--KYAAQRH-------- 477
            ...|...|.:|.:||...     |.:...|  .:.|.....:.:|..|  |||.:.|
  Rat   464 EDQIMRLERLQKEARGSFLPEEQDRLLSEL--RDEIRTLREQVEHHPRLAKYAMENHSLREENRK 526

  Fly   478 ------------LSAIAIA--------LSRVKCEDRDLLQG---------HYATITQEIDI---- 509
                        |.|.|||        :|..:..|:. |||         .:.|.|:::.:
  Rat   527 LKLLAPVKRAHELDAQAIARLEQAFSEVSSTETNDKG-LQGLPPKAIKEPSFFTSTEKLKVQLLQ 590

  Fly   510 --------KNDYIRKCKE--KIKMLEMEVSDLNS--EFQLDREDYLDEIRNLGRQV-----KFHQ 557
                    |.:| .:.||  :.|.||:| |:|.|  :..|:.|:.|:..:...||.     |.|.
  Rat   591 IQTELNNSKQEY-EEFKELTRKKQLELE-SELQSLQKANLNLENLLEATKVCKRQEVSQLNKIHA 653

  Fly   558 QLFLKFSSNPGK---FDRNWTPDTILQNSLWNDDLKMWRIPESDLIK--LPPATQKSGLHCIHPL 617
            :. ||..:.|.|   ......|.:..:...:. .|:....|::|::.  :||...:..|..|
  Rat   654 ET-LKIITTPTKAYQLCSRLVPKSSPEVGSFG-FLRSQSAPDNDILNEPVPPEMSEQALEAI--- 713

  Fly   618 VIHSENQHNNQNEIVV 633
               ||.....|.::.|
  Rat   714 ---SEELRTVQEQLSV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	153/351 (44%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	149/346 (43%)
Kif15	XP_038937602.1	KISc_KLP2_like	25..373	CDD:276824	158/361 (44%)
		Smc	<361..1126	CDD:224117	87/381 (23%)
		SbcC	876..>1396	CDD:223496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910