DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif13b

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_998791.1	Gene:	Kif13b / 305967	RGDID:	1303307	Length:	1767	Species:	Rattus norvegicus

Alignment Length:	796	Identity:	225/796 - (28%)
Similarity:	340/796 - (42%)	Gaps:	227/796 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEI-------NEFAVSVTNPSARISQQKKFIFD--------SV 54
            :||.||.||||:.|.:.:.:.:|::       |....:::...|| .|.|.|.:|        ||
  Rat     6 VKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPINTNLSKGDAR-GQPKIFAYDHCFWSMDESV 69

  Fly    55 YNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIF 119
            .......:.::..:..:::::..:|||..||||||||.||::||.|.   ::..|:||:....:|
  Rat    70 REKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGT---ADQPGLIPRLCSGLF 131

  Fly   120 ERISMTTNVR--YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNA 182
            ||.....|..  :...|:|:|||||::||||:...:...:.  ::|...:|..|..|:...|.:.
  Rat   132 ERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLK--VREHSVLGPYVDGLSKLAVTSY 194

  Fly   183 NQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAG 247
            ......:..|||:|..|||.||:.|||||.:|.|||..:.:....|:   .|...||||||||||
  Rat   195 KDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGT---SGEKVGKLSLVDLAG 256

  Fly   248 SERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQDSLGGN 307
            |||..||||.||||||.|.||.||:.||.|||:|.|     .|.|.||:|||.||.||:||||||
  Rat   257 SERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGN 321

  Fly   308 TKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML---- 368
            :||.|::.:||...:||||:||||||.|||:|.|...:||||....:|..:.|:..|:..|
  Rat   322 SKTAMVATVSPAADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEVEKLREQLTKAE 386

  Fly   369 ------------------------------------QESQQ----------------------II 375
                                                ||.|:                      ::
  Rat   387 AMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLV 451

  Fly   376 NKNNDP--NKIIKSPLKIIQHTNMNS--TKNVQIIDLG---------------------RNCK-- 413
            |.|.||  |:::...||  :||.:.|  ::::|:..:|                     :|.:
  Rat   452 NLNADPALNELLVYYLK--EHTLIGSANSQDIQLCGMGILPEHGIIDIMPEGQVMLTPQKNTRTF 514

  Fly   414 ---------------------------------------------ASFKTNNS------------ 421
                                                         ||.|.::|
  Rat   515 VNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEEREASLKNDSSSEQLDADGDSSS 579

  Fly   422 -ILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIAL 485
             :.::.||....::.||.::|....|.::..|...|:.|:.|.:.....::...:..|..:...|
  Rat   580 EVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRL 644

  Fly   486 S--RVKCEDRDLLQGHYATITQ---------EIDIKNDYIRKCKEKIK--MLEMEVSDLNSEFQL 537
            |  |..|...|.|..|..:..|         |..:.|..:|..::.:|  :|..|.|.:..|  |
  Rat   645 SPERQNCRGVDRLSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREASYIAEE--L 707

  Fly   538 D-REDY----------LDEIRNLGR-------QVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSL 584
            | |.:|          ||..|..|.       ||:           ..||..:.|:.:. |:|.|
  Rat   708 DKRTEYKVTLQIPASSLDANRKRGSLLSEPAIQVR-----------RKGKGKQIWSLEK-LENRL 760

  Fly   585 --WNDDLKMWRIPESD 598
              ..|..:.|:..|.|
  Rat   761 LDMRDLYQEWKECEED 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	148/355 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	145/350 (41%)
Kif13b	NP_998791.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	150/362 (41%)
		KISc	6..360	CDD:214526	150/362 (41%)
		Kinesin_assoc	357..469	CDD:292801	18/113 (16%)
		FHA	447..544	CDD:238017	13/98 (13%)
		KIF1B	756..802	CDD:289208	7/21 (33%)
		C2	<888..>952	CDD:301316
		DUF3585	<1073..1143	CDD:304905
		DUF3694	<1211..1278	CDD:289256
		CAP_GLY	1644..1707	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910