Protein Alignment Kif3C and Kif19

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001402044.1
• Gene: Kif19 / 303659
• RGDID: 1559936
• Length: 997
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 199/725 - (27%)
• Similarity: 330/725 - (45%)
• Gaps: 139/725 - (19%)

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIV-EINEFAVSVTNP--------SARISQQKKFIFDSVYNMK 58
            :.:.|.:|.||::.:|.|.....|. :::|..|.:.:|        .|..|::|.::||..::..
  Rat    10 QQLMVALRVRPISVSELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFT 74

  Fly    59 TDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERIS 123
            ...|::|.....||:|..|.|||.|:||||.||||||:||.|.:   :..||..:..:.:|..|.
  Rat    75 ATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTD---HEPGIYVRTLNDLFRAIE 136

  Fly   124 MTTN-VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIG-----------VSVPTLTT 176
            .|:| :.|...::|||||||.||||||               |.:|           :.|..:|.
  Rat   137 ETSNDMEYEVSMSYLEIYNEMIRDLLN---------------PALGYLELREDSKGVIQVAGITE 186

  Fly   177 QPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLS 241
            ...:||.:....|..||:.|....|..|:.|||||.:..:.:.|...:.:|..:    :.:|:|.
  Rat   187 VSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRNRVKNILQE----VRQGRLF 247

  Fly   242 LVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-GKAKHVPFRDSKLTRLLQDSLG 305
            ::|||||||..:|..:|.|:||.:.||.||.||||.|::|.| |..|::.:|||||||||:||||
  Rat   248 MIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGGNKYINYRDSKLTRLLKDSLG 312

  Fly   306 GNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQ- 369
            ||::|:||:.|||....::|:.:||.||.|||||..:.|.|.......:.||.:.|..|:..:|
  Rat   313 GNSRTVMIAHISPASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQR 377

  Fly   370 ---ESQQIINKNNDPNKIIKSPLKIIQ--------------------------HTNMNSTKNVQI 405
               :..|...:.....|:.:..::.||                          |..|:..:  ::
  Rat   378 LKCKIDQQAGRGQARGKLDRGDIRHIQAEVQLHSGQEEQAEMGQLREQLISAFHEQMDVRR--RL 440

  Fly   406 IDL-GRNCKASFKTNNSILTKPNFP------LIQSKEEVQLQARSRIDLIKRSLIGGERIHDFEL 463
            ::| .:..:....|:..:||..::.      .::.:||.:.::.::.|..|.|..|.|. .:.|.
  Rat   441 LELENQAMEVQIDTSRHLLTIASWEHEKSRRALKWREERRKESYTKEDSEKDSDTGDEP-DNLEP 504

  Fly   464 KEKHMARKYAA-----QRHLSAIAIALSRVKC---------------------EDRDLLQGHYAT 502
            .|...||:..|     |:.|....:||.: :|                     |.|::|.  ...
  Rat   505 PEVASARENIAALVGEQKKLRKEKLALEQ-RCRELRARGRRLEETLPRRIGSEEQREVLS--LLC 566

  Fly   503 ITQEIDIKN-----------DYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFH 556
            ...|::::|           ..:|..:|.::.||...|..:...|..|:...|....:.|.::..
  Rat   567 RVHELEVENTEMQSHALLRDSALRHRREAVRRLEQHRSLCDEIIQGQRQIIDDYNLEIPRHLEEL 631

  Fly   557 QQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPA----TQKSGLHCIHPL 617
            .:::|: ....|..:|....|.:...:|          .:|.|.|:.||    |..|.|..:..|
  Rat   632 YEVYLR-ELEEGSLERATIMDRVASRAL----------QDSSLPKITPAGTTLTPDSDLESVKTL 685

  Fly   618 VIHSENQHNN 627
            ...::...||
  Rat   686 SSEAQCPQNN 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	133/357 (37%)
Kif19	NP_001402044.1	KISc_KIP3_like	11..346	CDD:276821	133/356 (37%)
		Smc	<340..>605	CDD:440809	49/270 (18%)