DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif7

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_218828.5	Gene:	Kif7 / 293047	RGDID:	1310310	Length:	1341	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	176/571 - (30%)
Similarity:	271/571 - (47%)	Gaps:	95/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEMC 69
            ::|.:|.||:...|.....|:.:::......:|     :.:.:.|.|..|.......|.:|....
  Rat    16 VRVALRVRPLLPKELLHGHQSCLQVEPERGRIT-----LGRDRHFGFHVVLGEDAGQEAVYQACV 75

  Fly    70 YSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFS----NSTGIIPKCFDHIFERISMTTNVRY 130
            ..|:|:..||:|.|:|||||||.|||:|| |:.:.:    :..||||:.....|:.|.....:..
  Rat    76 QPLLEAFFEGFNATVFAYGQTGSGKTYTM-GEASVASLHEDEQGIIPRAMAEAFKLIDENDLLDC 139

  Fly   131 LALVTYLEIYNERIRDL-----------LNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQ 184
            |..|:|||:|.|..|||           |.:::..||:...:||:             .|...::
  Rat   140 LVHVSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLCGVKEV-------------DVEGLDE 191

  Fly   185 CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQ---SPFLNSIGSDAFGGICRGKLSLVDLA 246
            ....|..||..|.|.||..|:.||||||:||:||||   :|  ..:.....|.:...|...||||
  Rat   192 VLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRAP--TRLPRPGAGHLLVSKFHFVDLA 254

  Fly   247 GSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKAKHVPFRDSKLTRLLQDSLGGNTK 309
            ||||..|||:.|:||||:.|||.:|.|||||||:|.|  .:..|:|:||||:||:|:||||||.|
  Rat   255 GSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAK 319

  Fly   310 TLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQI 374
            |:||:|:||:...:|||::||.|||||:||.|:..:|..|:..|:.:               :|.
  Rat   320 TVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERVPE---------------EQA 369

  Fly   375 INKNNDPNKIIKSPLKIIQHTNMNSTKNVQII----DLGRNC-------KASFKTNNSILTKPNF 428
            ......|..  :|..:||..........|...    .||..|       .|::.....:..:|..
  Rat   370 AGARGPPRH--RSETRIIHRGRRVLCPGVGSAAVAPGLGTECARCRARTSAAYSLLRELQAEPGL 432

  Fly   429 PLIQSKEEVQLQARSRIDLI-----KRSLIGGERIHDFELKEKHMARKYAAQ-----------RH 477
            |        ...||...|.:     :||.:......|..: |...|...|||           :.
  Rat   433 P--------GAAARKVRDWLCAVEGERSALSSASGPDSGI-ESAPADDQAAQGTSGRKGDEGAQQ 488

  Fly   478 LSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEV 528
            |..:...::|::.|:||.|.. .....::..:::|.:|:.:|::..|.:.:
  Rat   489 LLILQSQVARLEEENRDFLAA-LEDAMEQYKLQSDRLREQQEEMVELRLRL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	137/353 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	136/348 (39%)
Kif7	XP_218828.5	KISc	15..356	CDD:214526	140/360 (39%)
		KISc_KIF4	15..350	CDD:276823	138/354 (39%)
		COG1340	701..1040	CDD:224259
		Utp11	848..1028	CDD:295201
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910