DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif26b

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001155137.1	Gene:	Kif26b / 269152	MGIID:	2447076	Length:	2112	Species:	Mus musculus

Alignment Length:	365	Identity:	103/365 - (28%)
Similarity:	176/365 - (48%)	Gaps:	38/365 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVR-CRPMNQTEKERNCQNIVEINEFAVSVTNP---------SARISQ--QKKFIFDSVYNM 57
            :||::| |....:...|.:....|:..:..:::.:|         ..|.||  .|.|.||:|:..
Mouse   451 VKVMLRICSTSARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQVPPKMFAFDAVFPQ 515

  Fly    58 KTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI 122
            ......:.......:::|.:.|.:|.:|.:|....||::||.|.::...:.||||.....:|:.|
Mouse   516 DASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLGIIPCAISWLFKLI 580

  Fly   123 S---MTTNVRYLALVTYLEIY--NERIRDLLNK--------NENTNVINHFLKELPGIGVSVPTL 174
            :   ..|..|:...::.:|::  .|.:||||::        .::..|   :|.|.|..|..:...
Mouse   581 NERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGV---YLCEDPICGTQLQNQ 642

  Fly   175 TTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSR-SHTIFTITLEQSPFLNSIGSDAFGGICRG 238
            :......|.:...:|.....:|.:.....:::..| ||.:||:.:.|.....|......||  |.
Mouse   643 SELRAPTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRMEKSGKGGMSGG--RS 705

  Fly   239 KLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDS 303
            :|.|:||....:......:|     .|.:.||||||||||.:||:| :||:|:::||||.||::|
Mouse   706 RLHLIDLGSCVKALSKNREG-----GSGLCLSLSALGNVILALVNG-SKHIPYKESKLTMLLRES 764

  Fly   304 LGG-NTKTLMISCISPTDIHYDETISTLRYASRAKNISNK 342
            ||. |.:|.||:.||.....|.||:||::.|||...:..|
Mouse   765 LGNVNCRTTMIAHISAAASSYAETLSTIQIASRVLRMKKK 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	102/360 (28%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	100/355 (28%)
Kif26b	NP_001155137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..286
		KISc	450..798	CDD:276812	101/357 (28%)
		KISc	451..798	CDD:214526	101/357 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..859		103/365 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1165
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1405..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1649
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1748..1801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1899..1971
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900