DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF26A

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_056471.1	Gene:	KIF26A / 26153	HGNCID:	20226	Length:	1882	Species:	Homo sapiens

Alignment Length:	366	Identity:	100/366 - (27%)
Similarity:	176/366 - (48%)	Gaps:	37/366 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEIN--EFAVSVTNP------------SARISQQKKFIFDSVY 55
            :||::|..|....::.....:.::::  :..|.:.:|            :|..:..|.|.||:|:
Human   372 VKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRRAATAAVPKMFAFDAVF 436

  Fly    56 NMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFE 120
            ...::...:.......:::|.:.|.:|.||::|....||::||.|.::...|.||:|.....:|.
Human   437 PQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFR 501

  Fly   121 RIS---MTTNVRYLALVTYLEI--YNERIRDLL-----NKNENTNVINHFLKELPGIGVSVPTLT 175
            .|.   ..|..|:...|:.:|:  .::.:||||     ...::|.....:|:|.|..|..:...:
Human   502 LIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPGSLQDTQSPGVYLREDPVCGAQLQNQS 566

  Fly   176 TQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSR-SHTIFTITLEQSPFLNSIGSDAFGGICRGK 239
            ......|.:...:|......|.|:.....:::.| ||.:||:.:.|.. :...|.....| .|.:
Human   567 ELRAPTAEKAAFYLDAALAARSTSRAGCGEDARRSSHMLFTLHVYQYR-MEKCGRGGMSG-GRSR 629

  Fly   240 LSLVDLAGSERQRKTGAQGDRLKEAS--QINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQD 302
            |.|:||...|      |...|..||:  .:.|||||||:||.:||:| |||||:||.:||.||::
Human   630 LHLIDLGSCE------AAAGRAGEAAGGPLCLSLSALGSVILALVNG-AKHVPYRDHRLTMLLRE 687

  Fly   303 SLG-GNTKTLMISCISPTDIHYDETISTLRYASRAKNISNK 342
            ||. ...:|.||:.:|.....:.||:||::.|:|...:..|
Human   688 SLATAGCRTTMIAHVSDAPAQHAETLSTVQLAARIHRLRRK 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	99/361 (27%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	97/356 (27%)
KIF26A	NP_056471.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..337
		KISc	371..723	CDD:276812	99/359 (28%)
		KISc	372..731	CDD:214526	100/366 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..785		100/366 (27%)
		PRK07764	<844..1285	CDD:236090
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	851..915
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..993
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1335..1728
		COG3416	<1552..>1673	CDD:225950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900