DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and klp3

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_594686.1	Gene:	klp3 / 2542195	PomBaseID:	SPAC1834.07	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	547	Identity:	184/547 - (33%)
Similarity:	259/547 - (47%)	Gaps:	113/547 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIV-EINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            :||||.|.||.||.|::....|:: .:|:..|.:...    .....|:||.|::..:....|:.
pombe     3 SIKVVCRIRPTNQLEQDLGGNNVIYPLNDSTVHIETS----DYSGNFVFDRVFHPSSTQNDIFS- 62

  Fly    68 MCYSLVESTIE----GYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI-SMTTN 127
              || :|||::    |||||:.||||||.|||:||.|.||.....|:.|:....||::| ...:.
pombe    63 --YS-IESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPST 124

  Fly   128 VRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHF 191
            ..|...|:|:|||.|:|.|||: ||:...|....|:     ||.|..|.|..|.:..:..|.|:.
pombe   125 TEYEVKVSYMEIYMEKIHDLLSEKNDRLTVHEDKLQ-----GVYVQGLKTIYVSSETEALDILNK 184

  Fly   192 GNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGA 256
            |..:|..|:|.||..|||||:||.:.:.|:       ....|...||:|.||||||||...|:||
pombe   185 GMGSRAVASTSMNAQSSRSHSIFVLEVVQT-------DTESGETRRGRLFLVDLAGSESVGKSGA 242

  Fly   257 QGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDI 321
            .|..|:||.:||.|||.||.||:||.|.|..|||:|||||||:|::|||||::|.:|...||...
pombe   243 VGQTLEEAKKINRSLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSY 307

  Fly   322 HYDETISTLRYASRAKNISNKPKINED------------PKDARLR-----------QYQN---- 359
            :..||:||||:..|||:|.||..:|.:            .|||..|           .|.|
pombe   308 NATETLSTLRFGHRAKSIKNKAVVNSELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSN 372

  Fly   360 ----------------------EILYLKRMLQESQ---------QIINKNNDPNKI----IKSPL 389
                                  ||:...|.:|||.         .|...|.|.:.|    .::.|
pombe   373 VWSGEHSLTLSNLAEKSNLKEAEIIQGNRTIQESNNDRDESTVASIHRHNFDSDSINRLYAEAQL 437

  Fly   390 KIIQHTNMNSTKNVQIIDL----------------GRNCKASFKTNNSILTKPNFPLIQSKEEVQ 438
            ::.|...:.|:...|:.||                .....::...|||:..||.|.:.|..:...
pombe   438 ELKQRDGVLSSTKQQLSDLMTALGDAQERYVELVKNHRVNSNLTANNSLNDKPGFTIEQKDKNFS 502

  Fly   439 --------LQARSRIDLIKRSLIGGER 457
                    ||..|.:|....:|:..:|
pombe   503 INNERNNFLQKLSTLDSSLAALVNVQR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	145/341 (43%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	141/335 (42%)
klp3	NP_594686.1	KIP1	1..546	CDD:227392	184/547 (34%)
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	145/341 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I786
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960