DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif3C and KIF21B

DIOPT Version :10

Sequence 1:NP_651939.4 Gene:Kif3C / 43820 FlyBaseID:FBgn0039925 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001239029.1 Gene:KIF21B / 23046 HGNCID:29442 Length:1637 Species:Homo sapiens


Alignment Length:791 Identity:222/791 - (28%)
Similarity:347/791 - (43%) Gaps:193/791 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVT--NPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            :||.||.||....||...|       ....|||  .|...:.:.|.|.:|.|:::.|..|.||..
Human     9 VKVAVRIRPQLSKEKIEGC-------HICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYST 66

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNS---TGIIPKCFDHIFERISM----- 124
            ....|:|...||||.|:.||||||.|||:||....:.:.|   .||||:...|:|..|:.     
Human    67 CVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHLFGGIAERKRRA 131

  Fly   125 ----TTNVRYLALVTYLEIYNERIRDLLN-------KNENTNVINHFLKELPGIGVSVPTLTTQP 178
                .....:.....:||:|||.|.||.:       ::..:|:..|  ::..| |:....:|::.
Human   132 QEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIH--EDANG-GIYTTGVTSRL 193

  Fly   179 VVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLN--SIGSDAFGGICRG--- 238
            :.:..:....|..|..:|.||:|.||..|||||.||||.|.|.....  .:.::|..|:..|   
Human   194 IHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPP 258

  Fly   239 ---------KLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFR 292
                     |...||||||||.::|||.|:|.||...||..|.|||||||:|.|...|  |||:|
Human   259 SSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYR 323

  Fly   293 DSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKD------ 351
            |||||||||||||||::|:||:|:||:|..:.||::||:||:||:||.||..:|:|...      
Human   324 DSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISAL 388

  Fly   352 ----ARLR-------------------------------QYQNEILYLK---------------- 365
                |||:                               |.:|..|.|:                
Human   389 RAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVT 453

  Fly   366 -RMLQESQQIINKNNDPNKIIKSPL------------KIIQHTNMNSTKNVQIIDLGRN-CKASF 416
             .|.||:..::.|..|.|:.|.:.:            |:::...||.:       |.|: .:||.
Human   454 QLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNES-------LRRSLSRASA 511

  Fly   417 KTNNSILTKPNFPL--------IQSKEEVQLQARSRIDLIKRSLIGGER---------------I 458
            ::..|:...|..|.        ::...||..:|:..::.:|:..:...|               .
Human   512 RSPYSLGASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQ 576

  Fly   459 HDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKM 523
            .:.|..:::.|.:...:|..|.......|   ||.|...|...::   :|..:|    .:||...
Human   577 ENSEETDENEAEEEEEERDESGCEEEEGR---EDEDEDSGSEESL---VDSDSD----PEEKEVN 631

  Fly   524 LEMEVSDLNSEFQLDREDYLDEIRNLGRQVKF--HQQ----LFLKFSSNPGKFDRNWTPDTILQ- 581
            .:.:::||..|.:: ::..:||:.|..|:::.  ||.    :.|:......:.:|    |.:|| 
Human   632 FQADLADLTCEIEI-KQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLER----DRVLQN 691

  Fly   582 ------------NSLWNDDLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNN-----QN 629
                        |.:..|..|..|....||.|| .|.||.     |..::.:::::..     |.
Human   692 LSTMECYTEEKANKIKADYEKRLREMNRDLQKL-QAAQKE-----HARLLKNQSRYERELKKLQA 750

  Fly   630 EIVVGEKVSIS 640
            |:...:|..::
Human   751 EVAEMKKAKVA 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif3CNP_651939.4 Motor_domain 3..339 CDD:473979 145/370 (39%)
KIF21BNP_001239029.1 KISc_KIF4 7..371 CDD:276823 146/371 (39%)
CwlO1 379..>539 CDD:443091 25/166 (15%)
Interaction with TRIM3. /evidence=ECO:0000250|UniProtKB:Q9QXL1 400..1099 68/390 (17%)
Smc <472..>1064 CDD:440809 58/318 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..538 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..628 13/85 (15%)
EnvC 633..>842 CDD:443969 29/140 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..906
Rcc_KIF21B 929..1010 CDD:410203
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1194..1251
WD40 1305..1613 CDD:238121
WD 1 1306..1343
WD40 repeat 1312..1346 CDD:293791
WD 2 1346..1384
WD40 repeat 1351..1387 CDD:293791
WD40 repeat 1407..1450 CDD:293791
WD 3 1410..1448
WD 4 1451..1493
WD40 repeat 1456..1500 CDD:293791
WD 5 1502..1539
WD40 repeat 1509..1541 CDD:293791
WD 6 1543..1582
WD40 repeat 1548..1572 CDD:293791
WD 7 1585..1622
Blue background indicates that the domain is not in the aligned region.

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