DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF6

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_005248961.1	Gene:	KIF6 / 221458	HGNCID:	21202	Length:	842	Species:	Homo sapiens

Alignment Length:	821	Identity:	204/821 - (24%)
Similarity:	323/821 - (39%)	Gaps:	241/821 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARI--------------SQQKKFIF 51
            :.:.|::..|.:|    ...::.|.|..|:|....:  ||..|              .:..||.|
Human     2 VKQTIQIFARVKP----PVRKHQQGIYSIDEDEKLI--PSLEIILPRDLADGFVNNKRESYKFKF 60

  Fly    52 DSVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFD 116
            ..:::...:.|.:::.:...:..|.:.|||||||||||||.|||.|:.|.....:..||||:...
Human    61 QRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLS 125

  Fly   117 HIFERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLK----ELPGIGVSVPTLTTQ 177
            :|||::...::..|...::|||||||...|||:.....:.:....|    |.|...:.:..||..
Human   126 YIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLH 190

  Fly   178 PVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITL-EQSPFLNSIGSDAFGGICRGKLS 241
            ......:..:.|..|:.||:.|.|.||:.|:|||.||||.| .:.|     ||   ..:...||.
Human   191 QATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEP-----GS---ATVRHAKLH 247

  Fly   242 LVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGG 306
            |||||||||..|||..|..|.||..|||||..|..||.:|.:....|:|:|:|.:|.:|:|||||
Human   248 LVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGG 312

  Fly   307 NTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINED--PKDARLRQYQNEILYLKRML- 368
            |..|.||:.:|....:.||:|||.|:|.|...|.|:..:||:  |: ..:::.|.||..||..|
Human   313 NCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPR-LVIKRLQKEIQELKDELA 376

  Fly   369 -----------------------------QESQQIINKNNDPNKI------IKSPL---KIIQHT 395
                                         |:|...:....|..|:      :|..|   ||:::.
Human   377 MVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENN 441

  Fly   396 NMNSTK----------------------------NVQIIDLGRNCKAS----------------- 415
            .::|..                            |:.:..|.:..|.:
Human   442 TVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQS 506

  Fly   416 ----FKTNN-------------------SILTKPNFPL---IQSKEEVQLQARSRIDLIKRSLIG 454
                |:..|                   |||.|.:..|   |..:||:.|..:...::.||....
Human   507 QSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFKRDHAD 571

  Fly   455 ---------------------GERIHDFELKEKHMARKYAAQRHLSAIAIALS------------ 486
                                 ||.|::...|..|: ::...|||:..:|:.:|
Human   572 SVTIDDNKQILKQRFSEAKALGESINEARSKIGHL-KEEITQRHIQQVALGISENMAVPLMPDQQ 635

  Fly   487 ----RVKCEDRDLLQGHYATI-----TQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDY 542
                |.:.|:.   :..|.|:     ..:::|::..:...|.|:|        |..||::   .:
Human   636 EEKLRSQLEEE---KRRYKTMFTRLKALKVEIEHLQLLMDKAKVK--------LQKEFEV---WW 686

  Fly   543 LDEIRNLGRQVKF-------HQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPES--- 597
            .:|..||  ||..       |.:.||:.|.:    ...|:      ..|.|.....|.:.:.
Human   687 AEEATNL--QVNSPAVNSLDHTKPFLQTSDS----QHEWS------QLLSNKSSGGWEVQDQGTG 739

  Fly   598 -------DLIKLPPATQKSGLHCIHPLVIHSENQHNNQNEI 631
                   :..|:.|:.      |..|   ||:.|.:....:
Human   740 RFDVCDVNARKILPSP------CPSP---HSQKQSSTSTPL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	127/354 (36%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	126/347 (36%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	127/351 (36%)
KIF6	XP_005248961.1	Kinesin	11..345	CDD:278646	126/347 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810