Protein Alignment Kif3C and Kif15

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_034750.1
• Gene: Kif15 / 209737
• MGIID: 1098258
• Length: 1387
• Species: Mus musculus
• Alignment Length: 665
• Identity: 215/665 - (32%)
• Similarity: 313/665 - (47%)
• Gaps: 127/665 - (19%)

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSV---------TNPSARISQQKKFIFDSVYNMKTD 60
            |||.||.||..:..:..:.:     ..|.:||         :||     ..|.|:||.|..|.|.
Mouse    27 IKVFVRIRPAEEGARSADGE-----QSFCLSVLSQTTLRLHSNP-----DPKTFVFDYVAGMDTT 81

  Fly    61 TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG---DENFS-NSTGIIPKCFDHIF-- 119
            .|.::..:..|:|||.:.|||||||||||||.|||.||.|   .:||| |..||||:.|:::|
Mouse    82 QESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGIIPRSFEYLFSL 146

  Fly   120 ---ERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVN 181
               |:........:|...:::|:|||:|.|||:...    :..:|:|....||.|.....|.|.:
Mouse   147 IDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSAS----VGLYLREHIKKGVFVVGAVEQAVTS 207

  Fly   182 ANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLE----QSPFLNSIGSDAFGGICRGKLSL 242
            |.:.|..|..|.:||..|:|.||:.|||||.:||||:|    .|..:|         |....|:|
Mouse   208 AAETYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSETVN---------IRTSLLNL 263

  Fly   243 VDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD---GKAKHVPFRDSKLTRLLQDSL 304
            |||||||||:.|.|:|.|||||..||.|||.||.||::|||   ||.:|:.:||||||.||:|||
Mouse   264 VDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSL 328

  Fly   305 GGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQ 369
            |||.||.:|:.:.|....:.||:|||.:|.|||.|.||..:|||.: ..:.|.|.|:..||..|.
Mouse   329 GGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLKEQLS 392

  Fly   370 E-------SQQIINKNNDPNKIIKSPLKII-------QHTNMNSTKNVQIIDLGRNCKASFKTNN 420
            :       .:.::.::.:....|:..|:.:       |.......|..|:.||... |..|..:|
Mouse   393 QFTSGQITPESLLARDKEKTNYIEYFLEAMLFFKKSEQEKKSLIEKITQLEDLTLK-KEKFIQSN 456

  Fly   421 SILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMAR-----KYAAQRH--- 477
            .::.|.....|...|.:..:.|......::..:..|...:.:...:|:..     |||.:.|
Mouse   457 KMIVKFREDQIMRLERLHKEGRGSFLPEEQDRLLSELRDEVQTLREHVEHHPRLAKYAMENHSLR 521

  Fly   478 -----------------LSAIAIA--------LSRVKCEDRDL-------------------LQG 498
                             :.|.:||        :|..:..|:.|                   |:.
Mouse   522 EENRRLKLLAPVKRAHEIDAQSIARLEKAFAEVSSTETNDKGLQGFSPKALKESSFFTNTEKLKA 586

  Fly   499 HYATITQEIDIKNDYIRKCKE--KIKMLEMEVSDLNS--EFQLDREDYLDEIRNLGRQV-----K 554
            ....|..|::.......:.||  :.|.||:| |:|.|  :..|:.|:.|:..:...||.     |
Mouse   587 QLLQIQTELNNSKQEYEEFKELTRKKQLELE-SELQSLQKANLNLENLLEATKVCKRQEVSQLNK 650

  Fly   555 FHQQLFLKFSSNPGK 569
            .|.:. ||..:.|.|
Mouse   651 LHAET-LKIITTPTK 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	154/358 (43%)
Kif15	NP_034750.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		KISc_KLP2_like	25..373	CDD:276824	159/368 (43%)
		SMC_prok_B	520..1339	CDD:274008	29/147 (20%)