DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and klp-13

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001360738.1	Gene:	klp-13 / 180865	WormBaseID:	WBGene00002224	Length:	678	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	201/717 - (28%)
Similarity:	320/717 - (44%)	Gaps:	173/717 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNC-QNIVEINEFAVSVTNPS------ARISQQ--KKFIFDSVYNMK 58
            :.:.||||.||:|..||.|.. |.:..:::..|.:.:|.      .|.::|  :||.||:.:...
Worm     6 QQLTVVVRVRPLNSGEKSRKAFQCVFPLDKKRVLLVDPEKFENNILRQNRQHERKFEFDASFGAT 70

  Fly    59 TDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERIS 123
            ::.|.:::.....:::|.:||:|.|:||||.||.|||.||.|.:   :..|::......::|::
Worm    71 SNQEDVHETTTGPIIDSVVEGFNATVFAYGATGSGKTFTMIGTK---DRPGLMTLMTKTLYEKL- 131

  Fly   124 MTTNVRYLALVTYLEIYNERIRDLLN---------KNENTNVINHFLKELPGI-GVSVPTLTTQP 178
               :.:|..|::|:|||||.||||||         ::|..|:      .:||: .|..|.||
Worm   132 ---DNQYQVLLSYMEIYNEIIRDLLNPSGGDLELLEDERGNI------RVPGLSSVKAPNLT--- 184

  Fly   179 VVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLV 243
                 :....|..||..|...||:.||.|||||.:..:.:.::..|:|            ||.::
Worm   185 -----RIMQILQEGNLRRTQEATMANKTSSRSHALLQVMIVKNQSLHS------------KLFMI 232

  Fly   244 DLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNT 308
            |||||||...|..:|.||||.:.||.||.||||||:||.....|.|.:|||||||||:|||||..
Worm   233 DLAGSERASNTQNRGIRLKEGAAINRSLLALGNVINSLASKTTKFVNYRDSKLTRLLKDSLGGTA 297

  Fly   309 KTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQ 373
            ||.||:.::|:..:::||.:||.|||||.||:|||..|. |..|            .::..|:..
Worm   298 KTCMIAHVTPSSSNFEETYNTLMYASRAMNITNKPMRNR-PASA------------DQVYAEAMN 349

  Fly   374 IINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPL-------- 430
            .|.|  :....||:...|   |.:.:..:||.....||...|...|:| ||:...|:
Worm   350 AIRK--EVGSQIKNSSSI---TGLAARSSVQERSSSRNRPKSISRNSS-LTRAAQPMPIDRGRGG 408

  Fly   431 ---IQSKEEVQLQARSRIDLIKRSLIGGERIHDFELK-----------EKHMARKYAAQRHLSAI 481
               .|.||:....:..:..|.::.:...:..:..|:.           |||         |....
Worm   409 SLFTQLKEQYMTLSDKQKRLREKLMATNQEAYSLEMSLISKNAIINAWEKH---------HHDKT 464

  Fly   482 AIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEK------------------------IK 522
            |.::.|:| :|.:|.:.....::.:.......:||.:|.                        :|
Worm   465 AESIERLK-KDGELQRVRLVELSDQRTKVEKALRKGEENASGLESRMRSLASTNEQREVVKLMVK 528

  Fly   523 MLEMEVSDLNSEFQL-------DREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTIL 580
            |.|:|...:::...|       ||.|     .::.:..|:..                 ..|.::
Worm   529 MAEIEAQKISALSDLAIRGLIMDRTD-----TSIAKLQKYEM-----------------VADKLI 571

  Fly   581 QNSLWNDDLKMWRIPESDLIK-------LP---PATQKSGLHCIHPLVIHSENQHNNQNEIVVGE 635
            ...|.::|.|... .|..:||       ||   ..|..|....:.|.:|      ||.|.|::.:
Worm   572 DGKLDDNDRKKLE-EEYRVIKNQFHYHLLPLKNIQTTVSWNSMLLPKII------NNNNTIIIED 629

  Fly   636 KV 637
            ::
Worm   630 RL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	133/354 (38%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	130/347 (37%)
klp-13	NP_001360738.1	Motor_domain	7..328	CDD:354959	133/353 (38%)
klp-13	NP_001360738.1	iSH2_PI3K_IA_R	413..>513	CDD:355389	17/109 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910