Protein Alignment Kif3C and klp-6

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_498069.1
• Gene: klp-6 / 175683
• WormBaseID: WBGene00002218
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 205/698 - (29%)
• Similarity: 328/698 - (46%)
• Gaps: 145/698 - (20%)

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEI-NEFAVSVTNPSARISQQKKFIFDSVY-------NMK- 58
            ::|.|.||.||.|..||.|||:.::|: :|....:.:|  :.:.:|:|.:|..|       ..|
 Worm     5 DSIIVAVRVRPFNDREKTRNCKLVIEMPDEETTVIRDP--KTNDEKRFTYDHSYWSHDGFSEKKN 67

  Fly    59 ----------TDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPK 113
                      .|...:::::...::.:...|||.::|||||||.||::::.|   |.|:.||:|.
 Worm    68 GYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVG---FKNNKGIVPI 129

  Fly   114 CFDHIFERI--SMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLK--ELPGIGVSVPTL 174
            ..:.:|::|  :...|:::...|:.:|||.|::||||:   :|......||  |.|..|..|..|
 Worm   130 VCEELFKQIADNKKKNMQFEVFVSMMEIYCEKVRDLLS---STPPPKGGLKVREHPKNGFYVENL 191

  Fly   175 TTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGG--ICR 237
            ||.||.:..:....:..|.|:|..|||.||..|||:|||..||..|.      .|...||  :.:
 Worm   192 TTVPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQK------SSKQAGGTSMKK 250

  Fly   238 GKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD------GKAKHVPFRDSKL 296
            .:::||||||||||...|.:||||||...||.||:.||.||.:|.|      ||...:|:|||.|
 Worm   251 SEINLVDLAGSERQSAAGTEGDRLKEGIVINQSLTTLGRVIKALHDSQKAKSGKKTQIPYRDSVL 315

  Fly   297 TRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEI 361
            |.||:::||||:||:||:.|||.||:::||:||||:|.|||:|.....:||:..:..||:.:.|.
 Worm   316 TCLLKNALGGNSKTIMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNENQTERALRELREEN 380

  Fly   362 LYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKP 426
            |.|     :||                   ||........|.:|..|.|....:.|
 Worm   381 LRL-----QSQ-------------------IQGGTAGDASNEEIEKLRRQLAENQK--------- 412

  Fly   427 NFPLIQSKEEVQLQARSRI--DLIKRSLIGGERIHDFELKEKHMARKY-----AAQRHLSAIAIA 484
                  ..||::...:.:|  :..|.:....|:: :.|.|:|.|...:     .|..::....|.
 Worm   413 ------EMEEMEKSWQQKIAEEAAKHASGASEKV-EMEAKKKKMCHLWNLNEDPALTNVIVHFIP 470

  Fly   485 LSRVKCEDRDLLQGHY------ATITQEIDIKND-----YIRKCKEKIKMLEMEVSDLNSEFQLD 538
            :......::....|::      :.:.|.:.:|||     ::..|.|.:.:. :....::.|.||.
 Worm   471 VGESVVGNKPTSSGNFIQMSGLSILPQHVTLKNDGNNQIHLSPCSEDLDIF-INGKPVHGETQLQ 534

  Fly   539 REDYLDEIRNLGRQVKF---HQQLFLKFSSNPGKFDRNWTPDTILQN-----------SLWNDDL 589
            :.|          :|.|   |..:|    :||.|  :....|...:|           :|.|..|
 Worm   535 QND----------RVFFGGNHLYVF----NNPTK--KGIRTDITYENAQAEIAQNHAAALGNRGL 583

  Fly   590 ----KMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNNQNEIVV 633
                |...|.|.:|:...|..|::.       .:.:|...|.:.|||:
 Worm   584 GGGSKRDLILEEELMSTLPLVQRAN-------AMATELGRNVKFEIVL 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	143/366 (39%)
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	144/373 (39%)
		tolA	<366..>446	CDD:236545	21/119 (18%)
		FHA_KIF28P	450..552	CDD:438761	17/116 (15%)
		KIF1B	659..699	CDD:463574