DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and unc-104

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001022041.2	Gene:	unc-104 / 174144	WormBaseID:	WBGene00006831	Length:	1628	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	220/721 - (30%)
Similarity:	319/721 - (44%)	Gaps:	161/721 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVY--------NMKTD 60
            ::||.||.||.||.|.....:.::::|....::...|.. .:...|.||..|        :..|.
Worm     3 SVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSIN-KENFSFNFDHSYWSFARNDPHFITQ 66

  Fly    61 TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125
            .:| |:|:...::|...||||..||||||||.||::||.|..|..:..||||:..:.:|.||...
Worm    67 KQV-YEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDNN 130

  Fly   126 T--NVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDW 188
            .  :|:|...|:|:|||.||::||||.|...|:   .::|.|.:|..|..||...|.:.:...:.
Worm   131 NDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNL---RVREHPLLGPYVDDLTKMAVCSYHDICNL 192

  Fly   189 LHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRK 253
            :..|||.|..|||.||..|||||.:|||.|.|.........|...   ..|:||||||||||...
Worm   193 MDEGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEK---HSKISLVDLAGSERANS 254

  Fly   254 TGAQGDRLKEASQINLSLSALGNVISSLVDGKAKH-------VPFRDSKLTRLLQDSLGGNTKTL 311
            |||:|.||||.:.||.||:.||.|||.|.:...|.       :|:|||.||.||:::||||:||.
Worm   255 TGAEGQRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTA 319

  Fly   312 MISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQ-QII 375
            |::.:||.||::|||:||||||.|||.|..:..:||||....:|:...|::.|:.:|::.. .:.
Worm   320 MLAALSPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGIDVT 384

  Fly   376 NKNNDPNKIIKSP----------------------------LKIIQHTNMNSTKNVQIIDLGRNC 412
            :....|.|..|.|                            .|:|....:...:..::.|:|..|
Worm   385 DVQETPGKHKKGPKLPAHVHEQLEKLQESEKLMAEIGKTWEQKLIHTEEIRKQREEELRDMGLAC 449

  Fly   413 KASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRS---------------LIGGERI---- 458
             |...|...:.:....|.:.:..|..|.:...|..:|..               |:.||.|
Worm   450 -AEDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGRPEAEHRPDILLSGEAILELH 513

  Fly   459 --------------------------------------------HDFELKEKHMARKYAAQRHLS 479
                                                        |.|...:...||:  ::.:|:
Worm   514 CEFINEDGNVTLTMKPNASCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQEARQ--SRHNLA 576

  Fly   480 AIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDRE---- 540
            |||......|...::||.      .|.||:|.|     .|| ||||||......:.:|:::
Worm   577 AIAEQPIDWKYAQQELLD------KQGIDLKAD-----MEK-KMLEMESQYRREKVELEQKMYHQ 629

  Fly   541 --DYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSL--------WNDDLK----- 590
              :|...|.||.:||...|    .:.|..|..   |..:.:|.:||        |..|.|
Worm   630 TREYESMIENLQKQVDLAQ----SYISGGGSI---WEGERMLTSSLLEFPEELKWTSDQKRVVLK 687

  Fly   591 ---MWR 593
               .||
Worm   688 AAIKWR 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	148/351 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	145/345 (42%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	149/358 (42%)
		KISc	3..354	CDD:214526	149/358 (42%)
		Kinesin_assoc	351..488	CDD:292801	24/137 (18%)
		FHA	464..563	CDD:238017	11/98 (11%)
		KIF1B	829..874	CDD:289208
		DUF3694	1162..1261	CDD:289256
		PH_KIFIA_KIFIB	1500..1602	CDD:269939
		PH	1505..1602	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910