Protein Alignment Kif3C and Kif5b

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 556
• Identity: 175/556 - (31%)
• Similarity: 281/556 - (50%)
• Gaps: 96/556 - (17%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEI-NEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            ||||:.|.||:|::|..|..:.:.:. .|..|.:.:        |.:.||.|:...|..|.:|::
Mouse     8 NIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIAS--------KPYAFDRVFQSSTSQEQVYND 64

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI-SMTTNVRYL 131
            ....:|:..:|||||||||||||..||||||:|..:.....||||:....||..| ||..|:.:.
Mouse    65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFH 129

  Fly   132 ALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNKNR 196
            ..|:|.|||.::|||||:.::....::.....:|    .|...|.:.|.:.::..|.:..|..||
Mouse   130 IKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVP----YVKGCTERFVCSPDEVMDTIDEGKSNR 190

  Fly   197 VTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRL 261
            ..|.|.||::|||||:||.|.::|.   |:.......    |||.||||||||:..||||:|..|
Mouse   191 HVAVTNMNEHSSRSHSIFLINVKQE---NTQTEQKLS----GKLYLVDLAGSEKVSKTGAEGAVL 248

  Fly   262 KEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDET 326
            .||..||.||||||||||:|.:| :.:||:||||:||:||||||||.:|.::.|.||:..:..||
Mouse   249 DEAKNINKSLSALGNVISALAEG-STYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESET 312

  Fly   327 ISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQIINKNNDPNKIIKSPLKI 391
            .|||.:..|||.|.|...:|                 ::...::.::...|..:.||.:::.::.
Mouse   313 KSTLLFGQRAKTIKNTVCVN-----------------VELTAEQWKKKYEKEKEKNKTLRNTIQW 360

  Fly   392 IQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGE 456
            ::: .:|..:|.:.:.:....                    .||:..|:|.:
Mouse   361 LEN-ELNRWRNGETVPIDEQF--------------------DKEKANLEAFT------------- 391

  Fly   457 RIHDFELKEKHMARKYAAQRHLSAIAIALS-----RVKCEDRDLLQGHYATITQEIDIKNDYIR- 515
                   .:|.:|  ..:.:..:|:.:|.|     |.|||:      ..|.:.:::|.|::.|.
Mouse   392 -------ADKDIA--ITSDKPAAAVGMAGSFTDAERRKCEE------ELAKLYKQLDDKDEEINQ 441

  Fly   516 --KCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNL 549
              :..||:|...::..:|.:..:.|:::...|:..|
Mouse   442 QSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	143/336 (43%)
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	143/336 (43%)
		SMC_prok_B	<417..803	CDD:274008	15/67 (22%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963