Protein Alignment Kif3C and Kif4

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_032472.2
• Gene: Kif4 / 16571
• MGIID: 108389
• Length: 1231
• Species: Mus musculus
• Alignment Length: 731
• Identity: 225/731 - (30%)
• Similarity: 352/731 - (48%)
• Gaps: 172/731 - (23%)

  Fly     1 MSENIK-----VVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTD 60
            |.|.:|     |.:||||:...|.:..||..:   .|...  .|...:...|.|.:|.|::..|:
Mouse     1 MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCL---SFVPG--EPQVVVGNDKSFTYDFVFDPSTE 60

  Fly    61 TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG----DENFSNSTGIIPKCFDHIFER 121
            .|.:::.....|::...:|||.|:.||||||.|||::|.|    ::...::.|:||:....:|:.
Mouse    61 QEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKE 125

  Fly   122 ISMTTNVRYLALVTYLEIYNERIRDLL-NKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQC 185
            |:..::..:...|:|||||||.|.||| :..|....||  ::|.|..|:.:..||.:.|:.|:..
Mouse   126 INKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQIN--IREDPKEGIKIVGLTEKTVLVASDT 188

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSER 250
            ...|..||.:|..|:|.||..|||||.||||::||..  .:..:.:|    |.||.|||||||||
Mouse   189 VSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRK--KNDKNSSF----RSKLHLVDLAGSER 247

  Fly   251 QRKTGAQGDRLKEASQINLSLSALGNVISSLVDG-KAKHVPFRDSKLTRLLQDSLGGNTKTLMIS 314
            |:||.|:||||:|...||..|..||||||:|.|. |...||:||||||||||||||||:.||||:
Mouse   248 QKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIA 312

  Fly   315 CISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQII---- 375
            |:||.|.:.:||::|||||.||:.|.|||.||.||:.|       |:.:||:.:|:.|.::
Mouse   313 CVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAA-------ELNHLKQQVQQLQILLLQAH 370

  Fly   376 ------NKNNDPNKIIKSPLKIIQHTNMNSTKNVQIID----LGRN-CKASFKT----NNSILTK 425
                  :.|.:|::.::|.::          ||..:::    |.|. .:|:.:|    ...|||:
Mouse   371 GGTLPGDINVEPSENLQSLME----------KNQSLVEENEKLSRGLSEAAGQTAQMLERIILTE 425

  Fly   426 PNFPLIQSK-EEVQLQARSRIDLIKRSLIGGERIHDFELKE------------------------ 465
            .....:.:| ||::..|..::||.|  |:  |.:.|.||||
Mouse   426 QANEKMNAKLEELRRHAACKVDLQK--LV--ETLEDQELKENIEIICNLQQVIAQLSDEAAACMT 486

  Fly   466 ----------------------------KHMARKYAAQRHL----SAIAI--ALSRVKCEDRDLL 496
                                        :|..|:....:.|    .|:|:  ||::...::.:.|
Mouse   487 ATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQL 551

  Fly   497 QGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNL---GRQVKFHQQ 558
            |          .|:..|    ::.||.||.||..|    |.::|:.:.|::..   ..|.|..::
Mouse   552 Q----------PIQFQY----QDNIKNLESEVLSL----QREKEELVLELQTAKKDANQAKLSER 598

  Fly   559 LFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSEN 623
            ...:.....|:.                .|||.....:|.|:||..:|:            |:.:
Mouse   599 RRKRLQELEGQI----------------ADLKKKLQEQSKLLKLKESTE------------HTVS 635

  Fly   624 QHNNQNEIVVGEKVSI 639
            :.|.:..::..::|.:
Mouse   636 KLNQEIRMMKNQRVQL 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	149/346 (43%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	147/342 (43%)
		Smc	<518..>1005	CDD:440809	34/180 (19%)
		Globular	1001..1231
		Pre-SET	<1082..1120	CDD:461530
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1212