Protein Alignment Kif3C and Kif21b

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001034561.1
• Gene: Kif21b / 16565
• MGIID: 109234
• Length: 1624
• Species: Mus musculus
• Alignment Length: 797
• Identity: 224/797 - (28%)
• Similarity: 345/797 - (43%)
• Gaps: 204/797 - (25%)

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVT--NPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            :||.||.||....||...|       ....|||  .|...:.:.|.|.:|.|:::.|..|.||..
Mouse     9 VKVAVRIRPQLSKEKIEGC-------HICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYST 66

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNST-----GIIPKCFDHIFERISM--- 124
            ....|:|...||||.|:.||||||.|||:||  ...|...|     ||||:...|:|..|..
Mouse    67 CVSKLIEGCFEGYNATVLAYGQTGAGKTYTM--GTGFDTVTSEEEQGIIPRAIAHLFRGIDERKR 129

  Fly   125 ------TTNVRYLALVTYLEIYNERIRDLLN-------KNENTNVINHFLKELPGIGVSVPTLTT 176
                  .|...:.....:||:|||.|.||.:       ::..:|:..|  ::..| |:....:|:
Mouse   130 RAQEKGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIH--EDANG-GIYTTGVTS 191

  Fly   177 QPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQ-----SPFLNSIGSDAFGGIC 236
            :.:.:..:....|..|..:|.||:|.||..|||||.||||.|.|     .|   .:.::...|:.
Mouse   192 RLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQP---DLVNETVTGLP 253

  Fly   237 RG-------------KLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK- 287
            .|             |...||||||||.::|||.|:|.||...||..|.|||||||:|.|...|
Mouse   254 DGAAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKV 318

  Fly   288 -HVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKD 351
             |||:||||||||||||||||::|:||:|:||:|..:.||::||:||:||:||.||..:|:|...
Mouse   319 VHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTS 383

  Fly   352 ----------ARLR-------------------------------QYQNEILYLK---------- 365
                      |||:                               |.:|..|.|:
Mouse   384 QQISALRAEIARLQMELMEYKAGKRVIGEDGTEGYSDLFRENAMLQKENGALRLRVKAMQEAIDA 448

  Fly   366 -------RMLQESQQIINKNNDPNKIIKSPL------------KIIQHTNMNSTKNVQIIDLGRN 411
                   .|.||:..::.|..|.|:.|.:.:            |:::...||.:       |.|:
Mouse   449 INNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNES-------LRRS 506

  Fly   412 -CKASFKTNNSILTKPNFPL--------IQSKEEVQLQARSRIDLIKRSLIGGER---------- 457
             .:||.:...|:...|..|.        ::...||..:|:..::.:|:..:...|
Mouse   507 LSRASARNPYSLGASPAGPAFGGSPATSMEDASEVIRKAKQDLERLKKKEVRQRRKSPEKEAFKK 571

  Fly   458 -----IHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKC 517
                 ..:.|..:::.|.:...:|..|.......|   ||.|...|...::   :|..:|    .
Mouse   572 RAKLQAENSEETDENEAEEEEEERDESGCEEEEGR---EDEDEDSGSEESL---VDSDSD----P 626

  Fly   518 KEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKF--HQQ----LFLKFSSNPGKFDRNWTP 576
            :||....:.:::||..|.:: ::..:||:.|..|:::.  ||.    :.|:......:.:|
Mouse   627 EEKEVNFQADLADLTCEIEI-KQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLER---- 686

  Fly   577 DTILQ-------------NSLWNDDLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNN- 627
            |.:||             |.:..|..|..|....||.|| .|.||.     |..::.:::::..
Mouse   687 DRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKL-QAAQKE-----HARLLKNQSRYERE 745

  Fly   628 ----QNEIVVGEKVSIS 640
                |.|:...:|..::
Mouse   746 LKKLQAEVAEMKKAKVA 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	147/376 (39%)
Kif21b	NP_001034561.1	KISc_KIF4	7..372	CDD:276823	148/377 (39%)
		SMC_N	367..>1095	CDD:481474	79/424 (19%)
		Interaction with TRIM3. /evidence=ECO:0000269|PubMed:24086586	401..1100		68/390 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..629		13/85 (15%)
		EnvC	634..>831	CDD:443969	29/140 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..866
		Rcc_KIF21B	930..1011	CDD:410203
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1199..1253
		WD40	1302..1615	CDD:238121
		WD 1	1308..1345
		WD40 repeat	1314..1348	CDD:293791
		WD 2	1348..1386
		WD40 repeat	1353..1389	CDD:293791
		WD40 repeat	1409..1452	CDD:293791
		WD 3	1412..1450
		WD 4	1453..1495
		WD40 repeat	1458..1502	CDD:293791
		WD 5	1504..1541
		WD40 repeat	1511..1543	CDD:293791
		WD 6	1545..1584
		WD40 repeat	1550..1574	CDD:293791