Protein Alignment Kif3C and Kif21a

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_017171930.1
• Gene: Kif21a / 16564
• MGIID: 109188
• Length: 1685
• Species: Mus musculus
• Alignment Length: 736
• Identity: 217/736 - (29%)
• Similarity: 322/736 - (43%)
• Gaps: 223/736 - (30%)

  Fly    10 RCRPMNQTEKERNCQNIVEINEFAVSVT--NPSARISQQKKFIFDSVYNMKTDTEVIYDEMCYSL 72
            |.||....||...|       ....|||  .|...:.:.|.|.||.|:::.:..|.||.:....|
Mouse    23 RIRPQLAKEKIEGC-------HICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKL 80

  Fly    73 VESTIEGYNGTIFAYGQTGCGKTHTMQG--DEN-FSNSTGIIPKCFDHIFERI--SMTTNVR--- 129
            :|...||||.|:|||||||.|||:||..  |.| .....|||.:...|:|:.|  ..|:.::
Mouse    81 IEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVRHLFKSIDEKKTSAIKNGL 145

  Fly   130 ----YLALVTYLEIYNERIRDLLN-------KNENTNVINHFLKELPG----IGVSVPTLTTQPV 179
                :.....:||:|||.:.||.:       ||:.:|:..|  ::..|    :||:..|:.|:|
Mouse   146 PPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIH--EDSTGGIYTVGVTTRTVNTEP- 207

  Fly   180 VNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITL---------------------EQSPF 223
             ...||   |..|..:|.||:|.||..|||||.||||.:                     |.||
Mouse   208 -EMMQC---LKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLISESSP- 267

  Fly   224 LNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKA 286
            :|...:      ...|...||||||||.::|||.|:|.||...||..|.|||||||:|.|  .:|
Mouse   268 MNEFET------LTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRA 326

  Fly   287 KHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKD 351
            .|||:||||||||||||||||::|:||:|:||:|..:.||::||:||:||:||.||..:|:|...
Mouse   327 THVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRAS 391

  Fly   352 ARLRQYQNEILYLKRMLQE---SQQIINKN-----ND----------PNKIIKSPLKIIQHT--- 395
            .::...::||..|:..|.|   .::||::.     ||          .|..::..:|.:|.|
Mouse   392 QQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDA 456

  Fly   396 ----------------------------NMNSTKNVQIIDLGRNCKASFKTNNSI---LTK---- 425
                                        ||..:...:|.||......|...|.::   ||:
Mouse   457 LRARITQLVSEQANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATAR 521

  Fly   426 -PNF-------PLIQS--KEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKY-------- 472
             |.|       |.|.|  ||.:::     |||.|:.|   |::...|.|:|...:|.
Mouse   522 SPYFSASSAFSPTILSSDKETIEI-----IDLAKKDL---EKLKRKEKKKKKRLQKLEESGREER 578

  Fly   473 --------------------AAQRHLSAIAIALSRVKC------------EDRDLLQGH------ 499
                                .:::..:.:.:..::...            |:.|.::|.
Mouse   579 SVAGKDDNADTDQEKKEEKGVSEKENNELDVEENQEVSDHEDEEEEEEDEEEEDDIEGEESSDES 643

  Fly   500 -------------YATITQEIDIKNDYI--------------RKCKEKIKMLEMEVSDLNSEFQL 537
                         .|.||.||.||...|              ::.:||:.||:.::.|.    ||
Mouse   644 DSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDT----QL 704

  Fly   538 DREDYLDEIRNLGRQVKFHQQ 558
            :|:..|   :|||....:.::
Mouse   705 ERDQVL---QNLGSVESYSEE 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	149/376 (40%)
Kif21a	XP_017171930.1	KISc_KIF4	23..380	CDD:276823	150/377 (40%)
		Cast	<372..846	CDD:431111	72/366 (20%)
		EnvC	650..>865	CDD:443969	20/80 (25%)
		Rcc_KIF21A	946..1027	CDD:410204
		WD40	1350..1663	CDD:238121
		WD40 repeat	1401..1460	CDD:293791
		WD40 repeat	1466..1501	CDD:293791
		WD40 repeat	1506..1550	CDD:293791
		WD40 repeat	1558..1591	CDD:293791
		WD40 repeat	1598..1634	CDD:293791