DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif17

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_034753.1	Gene:	Kif17 / 16559	MGIID:	1098229	Length:	1038	Species:	Mus musculus

Alignment Length:	937	Identity:	287/937 - (30%)
Similarity:	399/937 - (42%)	Gaps:	348/937 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEINEF--AVSVTNPSARISQQKKFIFDSVYNMKTDTEVI 64
            ||::||||||||||:.|:|.:||::|.::..  ...:.||.|.....|:|.||..|.::..||.|
Mouse     3 SESVKVVVRCRPMNKRERELSCQSVVTVDSARGQCFIQNPGAADEPPKQFTFDGAYYIEHFTEQI 67

  Fly    65 YDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNVR 129
            |:|:.|.|||...||||||||||||||.||:.||||..:.....||||:.|:|:||.:....|.:
Mouse    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPCQRGIIPRAFEHVFESVQCAENTK 132

  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194
            :|...:|||||||.:.|||..:....:   .|||.|..||.|..|:...|.|..||...:..|.|
Mouse   133 FLVRASYLEIYNEDVHDLLGADTKQRL---ELKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWK 194

  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259
            ||....|||||:|||||:||||.:|    :.::.......:..|||:||||||||||.||||.|:
Mouse   195 NRAVGYTLMNKDSSRSHSIFTINIE----IYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGE 255

  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324
            |||||::|||||||||||||:||||:.||:|:|||||||||||||||||||||::|:||.|.:||
Mouse   256 RLKEATKINLSLSALGNVISALVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYD 320

  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQES------QQIINKNNDPNK 383
            ||:||||||:|||||.|||:||||||||.||:||.||..||.:|.:.      ..:::....|..
Mouse   321 ETLSTLRYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGNLSALLSTQTPPGP 385

  Fly   384 I-----IKSPLKIIQHTN-------------------------------------MNSTKNVQII 406
            :     :.||..:.|.|.                                     |.::.:|::.
Mouse   386 VQSEEKLLSPTTVQQDTEAEKQLIREEYEERLARLKADYEAEQESRVRLQEDITAMRNSYDVKLS 450

  Fly   407 DLGRN----------------CKA----------------------------------------- 414
            .|..|                ||.
Mouse   451 TLQENLRKEKETEAILKAEVLCKTEVMSRAELASGPEYSPPLQYETAVKPTILSMPDMPPSGKVT 515

  Fly   415 --------------------SFKTN---------------------------------------- 419
                                ||::|
Mouse   516 KSQAPLAFEEPHGETSRSEFSFESNECSTLEDSATSEAFPGPEEFSNMEFSMAAALTESRYLPEE 580

  Fly   420 ----------------------------------------------------------------- 419

Mouse   581 YLGGQEAAASPLEAERYVQENEPSLEPLRILASLQDPFAEVEAKLARLSSTVAMSDSSQTVVPQI 645

  Fly   420 -------------------------NSIL-TKPNFPL---------------------------- 430
                                     |.:| |:|:..|
Mouse   646 PKQPSSADLLEPSDTKSEADVAVADNVVLGTEPDVNLRVAEEVVSEAETGVWMESEAQVAHVAQV 710

  Fly   431 -------------------------IQSKEEV----QLQARSRIDLIKRSLIGGERIHDFELKEK 466
                                     :.::||:    |.|..:|:.|:::.::|||:..:.:|:||
Mouse   711 SEEAQPQPLLAMVSVRRESVGVEVAVLTEEELQPVDQQQVLARLQLLEQQVVGGEQAKNKDLREK 775

  Fly   467 HMARK-YAAQRHLSAIAIALSRVKCEDRD----LLQGHYATITQEIDIKNDYIRKCKEKIKMLEM 526
            |..|| ||.:|....:| ||..   .|.|    :|...|.:|.:|:..|:..:.|.:.|::..|:
Mouse   776 HKRRKRYADERKKQLVA-ALQN---SDEDGGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEV 836

  Fly   527 EVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQL------FLKFSSNPGKFDRNWTPDTILQNSLW 585
            |:.||.|||||::.|||..||...|.....|||      .::...|....::      |.:.|.|
Mouse   837 EIKDLQSEFQLEKIDYLATIRRQERDSMLFQQLLEQVQPLIRRDCNYSNLEK------IRRESSW 895

  Fly   586 NDDLKMWRIPESDLIK-----LPPATQ 607
            ::|...|:||:..::|     :|..||
Mouse   896 DEDNGFWKIPDPIILKTSLPVVPTGTQ 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	185/337 (55%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	180/330 (55%)
Kif17	NP_034753.1	Motor_domain	4..335	CDD:277568	185/337 (55%)
		Kinesin	11..335	CDD:278646	180/330 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..401		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..559		3/55 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..657		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..940		3/7 (43%)
		AC_N	918..>1036	CDD:292831	3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835432
Domainoid	1	1.000	131	1.000	Domainoid score	I5142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5883
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1449
Isobase	1	0.950	-	0	Normalized mean entropy	S2602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0006941
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107365
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5033
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.810