DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif12

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001304281.1	Gene:	Kif12 / 16552	MGIID:	1098232	Length:	643	Species:	Mus musculus

Alignment Length:	483	Identity:	155/483 - (32%)
Similarity:	233/483 - (48%)	Gaps:	72/483 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYN-MKTDTEVIYDEM 68
            |:||:|.|||:..|..|..|:.:..:      ...:.::|....|.|.:|.: .:|..:|.....
Mouse    26 IQVVLRVRPMSTVELRRGEQSALHCS------GTRTLQVSPDVAFRFGAVLDGARTQEDVFRACG 84

  Fly    69 CYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNS-------TGIIPKCFDHIFERIS-MT 125
            ...|.|..:.|::.|:|.:||||.|||:|:.|.......       .||:.:.|..:.:|:. :.
Mouse    85 VKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFTWLLDRVQHLD 149

  Fly   126 TNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELP-----GIGVSVPTLTTQPVVNANQC 185
            :.|...|  :|||||||::.|||:....        :.||     ..|..|..|......:....
Mouse   150 SPVTLRA--SYLEIYNEQVWDLLSLGSP--------RPLPVRWTKARGFYVEQLRVVEFGSLEAL 204

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTI-----TLEQSPFLNSIGSDAFGGICRGKLSLVDL 245
            .:.|..|...|.:::..:|:.|||||.:.|:     |.:|.|.:: :|....|    |||..|||
Mouse   205 MELLQMGLSRRRSSSHTLNQASSRSHALLTLHISRPTSQQVPPVD-LGEPPVG----GKLCFVDL 264

  Fly   246 AGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFRDSKLTRLLQDSLGGNT 308
            ||||:...||:||..:.||:.||.||.|||:.||.|:|.:.|  |:||||||||:||.|||||..
Mouse   265 AGSEKVAATGSQGQLMLEANSINRSLLALGHCISLLLDPQRKQNHIPFRDSKLTKLLADSLGGRG 329

  Fly   309 KTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQ 373
            .|||::|:||:.....||:|||||||||:.|:.:|:..:.|.....:|.:||:|    .|||..:
Mouse   330 VTLMVACVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPGVKPPQQVENELL----RLQEENR 390

  Fly   374 IINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKA---SFKTNNSILTKPNFPLIQSKE 435
            .:....|.           .||........::....||...   .|...|..|.|
Mouse   391 HLRFQLDQ-----------MHTTAPGAHGARMAWAQRNLYGMLQEFMLENERLRK---------- 434

  Fly   436 EVQLQARSRIDLIK-RSLIGGERIHDFE 462
            |:: |.||..||.: ...:..:::||.|
Mouse   435 EMR-QLRSSRDLARAEQRVLAQQVHDLE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	127/354 (36%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	124/349 (36%)
Kif12	NP_001304281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KISc	25..358	CDD:276812	126/352 (36%)
		Kinesin	31..360	CDD:278646	124/349 (36%)
		Kinesin-relat_1	<379..464	CDD:289481	24/109 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810