Protein Alignment Kif3C and KIF19

DIOPT Version :9

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_016879639.1
• Gene: KIF19 / 124602
• HGNCID: 26735
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 184/603 - (30%)
• Similarity: 288/603 - (47%)
• Gaps: 103/603 - (17%)

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIV-EINEFAVSVTNP--------SARISQQKKFIFDSVYNMK 58
            :.:.|.:|.||::..|.|.....|. :::|..|.:.:|        .|..|::|.::||..::..
Human    10 QQLMVALRVRPISVAELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFT 74

  Fly    59 TDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERIS 123
            ...|::|.....||:|..|.|||.|:||||.||||||:||.|.:   ...||..:..:.:|..|.
Human    75 ATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTD---QEPGIYVQTLNDLFRAIE 136

  Fly   124 MTTN-VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIG-----------VSVPTLTT 176
            .|:| :.|...::|||||||.||||||               |.:|           :.|..:|.
Human   137 ETSNDMEYEVSMSYLEIYNEMIRDLLN---------------PSLGYLELREDSKGVIQVAGITE 186

  Fly   177 QPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLS 241
            ...:||.:....|..||:.|....|..|:.|||||.:..:|:.|...:.:|..:    :.:|:|.
Human   187 VSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQE----VRQGRLF 247

  Fly   242 LVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-GKAKHVPFRDSKLTRLL----- 300
            ::|||||||..:|..:|.|:||.:.||.||.||||.|::|.| |..|::.:|||||||||
Human   248 MIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKVPAT 312

  Fly   301 --------QDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQY 357
                    :||||||::|:||:.|||....::|:.:||.||.|||||..:.|.|.......:.||
Human   313 AGPGHWAPRDSLGGNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNVSYHIAQY 377

  Fly   358 QNEILYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLG--RNCKASFKTNN 420
            .:.|..|:..:|..::                ||.:.|.....:..|  |.|  |:.:|..:.::
Human   378 TSIIADLRGEIQRLKR----------------KIDEQTGRGQARGRQ--DRGDIRHIQAEVQLHS 424

  Fly   421 SILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIA--- 482
            ....|..  :.|.:|::....:.::|:.:|.|         ||:.:.|..:....|||..||
Human   425 GQGEKAG--MGQLREQLASAFQEQMDVRRRLL---------ELENRAMEVQIDTSRHLLTIAGWK 478

  Fly   483 -----IAL-----SRVKCEDRDLLQGHYATITQEIDI-KNDYIRKCKEKIKMLEMEVSDLNSEFQ 536
                 .||     .|.:|..:|..:....|...:.|| :...:...:|.|..|..|...|..: :
Human   479 HEKSRRALKWREEQRKECYAKDDSEKDSDTGDDQPDILEPPEVAAARESIAALVDEQKQLRKQ-K 542

  Fly   537 LDREDYLDEIRNLGRQVK 554
            |..|....|:|..||:::
Human   543 LALEQRCRELRARGRRLE 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	134/370 (36%)
		Kinesin	10..339	CDD:278646	133/363 (37%)
KIF19	XP_016879639.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910