DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif3C and Kif1b

DIOPT Version :10

Sequence 1:NP_651939.4 Gene:Kif3C / 43820 FlyBaseID:FBgn0039925 Length:649 Species:Drosophila melanogaster
Sequence 2:XP_038965095.1 Gene:Kif1b / 117548 RGDID:621520 Length:1825 Species:Rattus norvegicus


Alignment Length:687 Identity:220/687 - (32%)
Similarity:322/687 - (46%) Gaps:153/687 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 NIKVVVRCRPMN--QTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE---- 62
            ::||.||.||.|  :|.||..|  |:::...:.|:.||.......|.|.||..|...|..|    
  Rat     5 SVKVAVRVRPFNSRETSKESKC--IIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCF 67

  Fly    63 ----VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERIS 123
                .:|:::...::....||||..||||||||.||::||.|.:..|.: ||||:..:.:||:|:
  Rat    68 ASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQA-GIIPQLCEELFEKIN 131

  Fly   124 MTTN--VRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQC 185
            ...|  :.|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:....
  Rat   132 DNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTSYTDI 192

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTITL---EQSPFLNSIGSDAFGGICRGKLSLVDLAG 247
            .|.:..|||.|..|||.||:.|||||.:|||..   :|.|..| :.::..     .|:|||||||
  Rat   193 ADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETN-LSTEKV-----SKISLVDLAG 251

  Fly   248 SERQRKTGAQGDRLKEASQINLSLSALGNVISSL--VDG---------KAKHVPFRDSKLTRLLQ 301
            |||...|||:|.||||.:.||.||:.||.|||:|  ||.         |...:|:|||.||.||:
  Rat   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLR 316

  Fly   302 DSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKR 366
            ::||||::|.|::.:||.||:||||:||||||.|||.|.....|||||....:|:.:.|:..||.
  Rat   317 ENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKD 381

  Fly   367 ML--QESQQIINKNNDP---------NKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNN 420
            :|  |....||  :.||         .|.:|         :..:.|:..::........:|.|.:
  Rat   382 LLRAQGLGDII--DIDPLMDDYSGSGGKYLK---------DFQNNKHRYLLASENQRPGNFSTAS 435

  Fly   421 --SILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAI 483
              |:.:.|:...:.|  :..|.:.:.|.....|..|||.                          
  Rat   436 MGSLTSSPSSCSLNS--QAGLTSVTSIQERIMSTPGGEE-------------------------- 472

  Fly   484 ALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDE--- 545
            |:.|:|..::         |..|::      ...:||::..|        ..:::||..|.|   
  Rat   473 AIERLKESEK---------IIAELN------ETWEEKLRKTE--------AIRMEREALLAEMGV 514

  Fly   546 -IRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNS--LWNDDLKMW------RIPESDL-- 599
             ||..|..:              |.|....||..:..|.  |.::.|..:      |:.::|.  
  Rat   515 AIREDGGTL--------------GVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAER 565

  Fly   600 ---IKLPPATQKSGLHCIHPLVIHSENQHNNQNEIVV 633
               |.|..|..|.. |||.      .::.||..|::|
  Rat   566 RQDIVLSGAHIKEE-HCIF------RSERNNTGEVIV 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif3CNP_651939.4 Motor_domain 3..339 CDD:473979 155/361 (43%)
Kif1bXP_038965095.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 156/368 (42%)
Kinesin_assoc 358..555 CDD:465047 51/272 (19%)
FHA_KIF1B 530..639 CDD:438779 18/73 (25%)
GimC 662..>719 CDD:440992
KIF1B 845..892 CDD:463574
KIF1B <956..975 CDD:463574
DUF3694 1266..1422 CDD:463599
PH_KIFIA_KIFIB 1710..1808 CDD:269939
Blue background indicates that the domain is not in the aligned region.

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