DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and Kif1c

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_665884.2	Gene:	Kif1c / 113886	RGDID:	70928	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	153/382 - (40%)
Similarity:	217/382 - (56%)	Gaps:	26/382 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE------ 62
            ::||.||.||.|..|..::.:.:|.:.....|:.||.......|.|.||..|...|..|
  Rat     5 SVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSVEDPQFAS 69

  Fly    63 --VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISM- 124
              .:|.::...::....||||..||||||||.||::||.|.:. ....||:|:..:.:|.|:::
  Rat    70 QQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQE-PGQQGIVPQLCEDLFSRVNVN 133

  Fly   125 -TTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDW 188
             :..:.|...|:|:|||.||:|||||.....::   .::|.|.:|..|..|:...|.:.....|.
  Rat   134 QSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSL---RVREHPILGPYVQDLSKLAVTSYADIADL 195

  Fly   189 LHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPF--LNSIGSDAFGGICRGKLSLVDLAGSERQ 251
            :..|||.|..|||.||:.|||||.:|||...|...  |..:.|:..     .|:||||||||||.
  Rat   196 MDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKV-----SKISLVDLAGSERA 255

  Fly   252 RKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQDSLGGNTKTL 311
            ..:||:|.||||.:.||.||:.||.|||:|.|     .|:..:|:|||.||.||:::||||::|.
  Rat   256 DSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTA 320

  Fly   312 MISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368
            ||:.:||.||:|:||:||||||.|.|.|.....|||||....:|:.|.|:..|:.:|
  Rat   321 MIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRELL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	142/351 (40%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	139/345 (40%)
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	143/358 (40%)
		Kinesin_assoc	352..522	CDD:406567	10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435
		FHA	499..599	CDD:238017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	900..924
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	949..1100
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910