Protein Alignment Kif3C and KIF12

DIOPT Version :9

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_005251740.1
• Gene: KIF12 / 113220
• HGNCID: 21495
• Length: 669
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 159/530 - (30%)
• Similarity: 244/530 - (46%)
• Gaps: 120/530 - (22%)

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEIN-EFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEM 68
            |:||:|.|||:..|..|..|:::..: ...:.|:.|..  ..:..|.|.:|.:.....|.:: ..
Human    26 IQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQVSPPGG--GPEVAFRFGAVLDAARTQEDVF-RA 87

  Fly    69 C--YSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNS-------TGIIPKCFDHIFERISM 124
            |  ..|.|..:.|::.|:|.:||||.|||:|:.|.......       .||:.:.|..:.:|
Human    88 CGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFAWLLDR--- 149

  Fly   125 TTNVRYL-ALVT----YLEIYNERIRDLLNKNENTNVINHFLKELP-----GIGVSVPTLTTQPV 179
               |::| |.||    |||||||::||||:....        :.||     ..|..|..|.....
Human   150 ---VQHLGAPVTLRASYLEIYNEQVRDLLSLGSP--------RPLPVRWNKTRGFYVEQLRVVEF 203

  Fly   180 VNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTI-----TLEQSPFLNSIGSDAFGGICRGK 239
            .:.....:.|..|...|..:|..:|:.|||||.:.|:     |.:|.|.::. |....|    ||
Human   204 GSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQMPSVDP-GEPPVG----GK 263

  Fly   240 LSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFRDSKLTRLLQD 302
            |..|||||||:...||::|:.:.||:.||.||.|||:.||.|:|.:.|  |:||||||||:||.|
Human   264 LCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQSHIPFRDSKLTKLLAD 328

  Fly   303 SLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRM 367
            ||||...|||::|:||:.....||:|||||||||:.::.:|:..:.|...:.::.:.|:|    .
Human   329 SLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPVAKQPQRLETEML----Q 389

  Fly   368 LQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQ 432
            |||..:.:....|.                            .:||||..:.
Human   390 LQEENRRLQFQLDQ----------------------------MDCKASGLSG------------- 413

  Fly   433 SKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQ 497
                      :|:...:|:|.|  .:.:|.|:.:.: ||..:|...|             |||.|
Human   414 ----------ARVAWAQRNLYG--MLQEFMLENERL-RKEKSQLQNS-------------RDLAQ 452

  Fly   498 GHYATITQEI 507
            .....:.|::
Human   453 NEQRILAQQV 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	132/360 (37%)
		Kinesin	10..339	CDD:278646	129/355 (36%)
KIF12	XP_005251740.1	KISc	25..363	CDD:276812	131/358 (37%)
		Kinesin	31..365	CDD:278646	129/355 (36%)
		Kinesin-relat_1	<383..469	CDD:289481	25/151 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810