DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF3A

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001287720.1	Gene:	KIF3A / 11127	HGNCID:	6319	Length:	726	Species:	Homo sapiens

Alignment Length:	670	Identity:	258/670 - (38%)
Similarity:	364/670 - (54%)	Gaps:	114/670 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ--KKFIFDSVYNMKTDTEVIY 65
            :|:||||||||:|:.||....:..|.::|...::|......|.:  |.|.||:|:..::....:|
Human    13 DNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVY 77

  Fly    66 DEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTT-NVR 129
            :.....:::|.:||||||||||||||.|||.||:|........||||..|.|||..|:... :.|
Human    78 NLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTR 142

  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194
            :|..|:|||||||.:||||.|::...:   .:||.|.:||.:..|:...|.||:.....:..|:|
Human   143 FLVRVSYLEIYNEEVRDLLGKDQTQRL---EVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHK 204

  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259
            ||...||.||::|||||.|||||:|.|    ..|.|....:..|||.||||||||||.||||.|.
Human   205 NRSVGATNMNEHSSRSHAIFTITIECS----EKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQ 265

  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324
            |||||::||||||.||||||:|||||:.|||:|:||||||||||||||:||:|.:.|.|.|.:||
Human   266 RLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYD 330

  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQI--------------- 374
            |||||||||:|||||.||.:||||||||.|||:|.||..||:.|:|.::|
Human   331 ETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEE 395

  Fly   375 ----------------------------INKNND-------------PNKIIKSPLKIIQHTNMN 398
                                        |.|..|             |:|:|:...||.:.....
Human   396 GEVGEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAKIDEERKAL 460

  Fly   399 STKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGG-------- 455
            .|| :.:.:..|| ||     .:.|.|....|:::::|.|........|.|:.::||
Human   461 ETK-LDMEEEERN-KA-----RAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAE 518

  Fly   456 --ERI---HDFELKEKHMARKYAAQ--RHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDY 513
              |::   .:.||:|:   ||.|.|  |.|..        |.::|..::..|.::.:|...|...
Human   519 EQEKLLEESNMELEER---RKRAEQLRRELEE--------KEQERLDIEEKYTSLQEEAQGKTKK 572

  Fly   514 IRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTP-- 576
            ::|....:...:.|::||..|.|.:.|..|:.||.|.|:::. |.|.:.          |:.|
Human   573 LKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRL-QMLIID----------NFIPRD 626

  Fly   577 -DTILQNSL-WNDDLKMWRI 594
             ..:::|.: ||:|:..|::
Human   627 YQEMIENYVHWNEDIGEWQL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	176/338 (52%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	171/331 (52%)
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	176/338 (52%)
KIF3A	NP_001287720.1	SMC_prok_B	<450..>616	CDD:274008	44/184 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820