DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif3C and CENPE

DIOPT Version :10

Sequence 1:NP_651939.4 Gene:Kif3C / 43820 FlyBaseID:FBgn0039925 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001804.2 Gene:CENPE / 1062 HGNCID:1856 Length:2701 Species:Homo sapiens


Alignment Length:643 Identity:200/643 - (31%)
Similarity:299/643 - (46%) Gaps:142/643 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSEN--IKVVVRCRPMNQTEKERNCQNIVEINEFA----VSVTNPSARISQQKKFIFDSVYNMKT 59
            |:|.  :.|.||.||:|..|:        .:.|.|    .:..|...::...|.|.||.|::...
Human     1 MAEEGAVAVCVRVRPLNSREE--------SLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNE 57

  Fly    60 DTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISM 124
            .|:.:|:|:...:::|.|:||||||||||||..|||:||.|.|   :..|:||:....||::|..
Human    58 TTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSE---DHLGVIPRAIHDIFQKIKK 119

  Fly   125 TTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWL 189
            ..:..:|..|:|:|||||.|.|||...:....:  .::|.....|.|..||.:.|..:.....|:
Human   120 FPDREFLLRVSYMEIYNETITDLLCGTQKMKPL--IIREDVNRNVYVADLTEEVVYTSEMALKWI 182

  Fly   190 HFGNKNRVTAATLMNKNSSRSHTIFTITLEQ----SPFLNSIGSDAFGGICRGKLSLVDLAGSER 250
            ..|.|:|....|.||:.||||||||.:.||.    .|      |:..|.:....|:|||||||||
Human   183 TKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEP------SNCEGSVKVSHLNLVDLAGSER 241

  Fly   251 QRKTGAQGDRLKEASQINLSLSALGNVISSLVDGK-AKHVPFRDSKLTRLLQDSLGGNTKTLMIS 314
            ..:|||.|.||||...||.||..||.||..|.||: ...:.:|||||||:||:|||||.||.:|.
Human   242 AAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIIC 306

  Fly   315 CISPTDIHYDETISTLRYASRAKNISNKPKINEDPKD-ARLRQYQNEILYLKRMLQESQQIINKN 378
            .|:|  :.:|||::.|::||.||.:.|.|.:||...| |.|::|:.||:.||:.|:|        
Human   307 TITP--VSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE-------- 361

  Fly   379 NDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNF-PLIQSKEEVQLQAR 442
                                               .|.:|....:.|... .|::.|:.:|....
Human   362 -----------------------------------VSLETRAQAMEKDQLAQLLEEKDLLQKVQN 391

  Fly   443 SRIDLIKRSLIGGERIH-DFELKEKHMAR--------------KYAAQRHLSA--------IAIA 484
            .:|:.:.|.|:....:. ..|||.|...|              .||.|.::..        ::|.
Human   392 EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456

  Fly   485 LSR----VKCEDRDLLQGHYATITQ-----------------EID-IKNDY---------IRKCK 518
            |.|    ..|.:.|:......|:::                 |:: ::.||         :|..|
Human   457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK 521

  Fly   519 EKIKMLEMEVSDLNSEFQLDREDYLD-------EIRNLGRQVK----FHQQLFLKFSS 565
            |::::...|.:||:....|:|:...|       ||.||...||    ::|.|..:.||
Human   522 EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif3CNP_651939.4 Motor_domain 3..339 CDD:473979 140/346 (40%)
CENPENP_001804.2 KISc_CENP_E 6..329 CDD:276825 139/343 (41%)
SMC_prok_B 345..1131 CDD:274008 53/278 (19%)
SMC_prok_B 828..1715 CDD:274008
SMC_prok_B 1332..2129 CDD:274008
SMC_N 1730..>2573 CDD:481474
Kinetochore-binding domain 2126..2476
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2355..2376
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2508..2533
Globular autoinhibitory domain. /evidence=ECO:0000250 2510..2698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2701
Blue background indicates that the domain is not in the aligned region.

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