DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and kif13b

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_031758942.1	Gene:	kif13b / 100492799	XenbaseID:	XB-GENE-956968	Length:	1943	Species:	Xenopus tropicalis

Alignment Length:	738	Identity:	227/738 - (30%)
Similarity:	338/738 - (45%)	Gaps:	169/738 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEN-IKVVVRCRPMNQTEKERNCQNIVEI--NEFAVSVTNPS-----ARISQQKKFIFD----- 52
            ||:: :||.||.||||:.|.:...:.:|::  |:..:..:|.|     || ||.|.|.:|
Frog     1 MSDSTVKVAVRIRPMNRREVDLQTKCVVDVENNQIVLYPSNASLSKGDAR-SQPKVFAYDHCFWS 64

  Fly    53 ---SVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKC 114
               ||.......:|::..:..:::::..||||..||||||||.||::||.|.   ::..|:||:.
Frog    65 MDESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGT---ADQPGLIPRL 126

  Fly   115 FDHIFERISMTTN--VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQ 177
            ...:|||.....|  :.:...|:::|||||::||||:...:...:.  ::|...:|..|..|:..
Frog   127 CSTLFERTQKAENEELSFKVEVSFMEIYNEKVRDLLDPKGSRQSLK--VREHKVLGPYVDGLSKL 189

  Fly   178 PVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSL 242
            .|.:.......:..|||:|..|||.||:.|||||.:|.|.|..:  |..:.|...|... .||||
Frog   190 AVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHT--LVDVKSGTSGEKV-SKLSL 251

  Fly   243 VDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQD 302
            ||||||||..||||.|:||||.|.||.||:.||.|||:|.|     .|.|.||:|||.||.||:|
Frog   252 VDLAGSERATKTGAAGERLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKD 316

  Fly   303 SLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEI------ 361
            |||||:||.|::.:||...:||||:||||||.|||||.|...:||||....:|:.:.|:
Frog   317 SLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKNIVNHAVVNEDPNARIIRELREEVEKLRVQ 381

  Fly   362 ---------LYLKRMLQESQQII------------------------------------------ 375
                     ..||..||||:::|
Frog   382 LTQAESMKAPELKERLQESEKLIQEMTVTWEEKLRMTEDIAQERQKQLESLGISLQSSGIKVGDN 446

  Fly   376 -----NKNNDP--NKIIKSPLKIIQHTNMNS--TKNVQIIDLG---RNCKASFKTNNSILTKP-- 426
                 |.|.||  |:::...||  .||.:.|  ::::|:..||   .:|.........::..|
Frog   447 KSFLVNLNADPALNELLVYYLK--DHTLIGSHDSQDIQLCGLGILPEHCIIDISPEGQVILTPMK 509

  Fly   427 ------NFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKY-----AAQRHLSA 480
                  |...:  .:..|||...||      |.|........|.:|..|::.     ::.|:.|:
Frog   510 NTRTYVNGSAV--TKATQLQHGDRI------LWGNNHFFRISLPKKKKAKQEDEEQDSSLRNSSS 566

  Fly   481 IAIALSRVKCEDRDL-----------LQGHYATITQEIDIK----NDYIRKCKEKIKMLEMEVSD 530
            .         |..||           :..:|.....||.:|    ||.::...:.::....|  :
Frog   567 F---------EQLDLDGDSSSEGSSEVNFNYEYAQMEIMMKALGNNDPMQSILQSLEQQHEE--E 620

  Fly   531 LNSEFQLDR---EDYLDEIRNLGRQVKFHQQLFLKF---SSNPGKFDRNWTPDTILQNSLWNDDL 589
            ..|..:..|   |..||::|......|.|.:...:|   |.|..:..|.||.:   :.::.|..|
Frog   621 KRSALERQRLMYEHELDQLRRRLSPEKQHYRSMDRFSFGSPNAQQRIRQWTEE---REAMLNQSL 682

  Fly   590 KMWRIPESDLIKLPPATQKSGLH 612
            :          ||.....|:.||
Frog   683 R----------KLREQIAKANLH 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	150/358 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	147/350 (42%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	153/364 (42%)
		Kinesin_assoc	357..469	CDD:406567	20/113 (18%)
		FHA	449..544	CDD:238017	23/104 (22%)
		KIF1B	755..801	CDD:403579
		DUF3585	<1097..1141	CDD:419985
		DUF3694	<1185..1277	CDD:403614
		CAP_GLY	1810..1873	CDD:396049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910