DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and ZNF682

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_016882944.1	Gene:	ZNF682 / 91120	HGNCID:	28857	Length:	504	Species:	Homo sapiens

Alignment Length:	346	Identity:	85/346 - (24%)
Similarity:	149/346 - (43%)	Gaps:	58/346 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 QKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESK 214
            |:|:..:.:..|||:..|      :..:.:.|.:....:|:........|.|..:.:...::|.:
Human     7 QELLTFRDVTIEFSLEEW------EFLNPAQQSLYRKVMLENYRNLVSLGLTVSKPELISRLEQR 65

  Fly   215 -----FTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSK-TTLSFEEPILLPDSSSI 273
                 ....:|:..| |..|....:.|:.|:   ..:::..:.||.: .:...|:..|..|..::
Human    66 QEPWNVKRHETIAKP-PAMSSHYTEDLLPEQ---CMQDSFQKVILRRYGSCGLEDLHLRKDGENV 126

  Fly   274 ELVNETAAMTINNHRTLSNHTGNTGDLHALPSSV-PFRIGLHEGQVNDCLSTISQST--HQDNTD 335
            ....:...:          :.|....|..|||.: |:         |.|:...|:|:  :::|..
Human   127 GECKDQKEI----------YNGLNQCLSTLPSKIFPY---------NKCVKVFSKSSNLNRENIR 172

  Fly   336 ST--------GCGEMNLSEVTVSY-----TNDKKIACPHKGCNKHFRDSSAMRKHLHTH-GPRVH 386
            .|        .||::..|...:||     |.:|...|  :.|.|.|:..|.:.||...| |.:.:
Human   173 HTTEKLFKCMQCGKVFKSHSGLSYHKIIHTEEKLCIC--EECGKTFKWFSYLTKHKRIHTGEKPY 235

  Fly   387 VCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDAC 451
            .|.||||||...|.|.:|:.:||||||::|  |.|||.|........|.:||||::|:.|  :.|
Human   236 KCEECGKAFNWCSSLTKHKRIHTGEKPYKC--EECGKAFHWCSPFVRHKKIHTGEKPYTC--EDC 296

  Fly   452 NKKFAQSTNLKSHILTHAKAK 472
            .:.|.:.::|..|...|...|
Human   297 GRAFNRHSHLTKHKTIHTGKK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	13/45 (29%)
		C2H2 Zn finger	359..381	CDD:275368	7/21 (33%)
		COG5048	<386..515	CDD:227381	35/87 (40%)
		zf-C2H2	386..408	CDD:278523	10/21 (48%)
		C2H2 Zn finger	388..408	CDD:275368	10/19 (53%)
		zf-H2C2_2	401..426	CDD:290200	13/24 (54%)
		C2H2 Zn finger	416..438	CDD:275368	7/21 (33%)
		zf-H2C2_2	430..457	CDD:290200	9/26 (35%)
		C2H2 Zn finger	446..468	CDD:275368	5/21 (24%)
ZNF682	XP_016882944.1	KRAB	10..70	CDD:214630	9/65 (14%)
		KRAB	10..49	CDD:279668	6/44 (14%)
		C2H2 Zn finger	153..173	CDD:275368	5/28 (18%)
		C2H2 Zn finger	181..201	CDD:275368	5/19 (26%)
		C2H2 Zn finger	209..229	CDD:275368	7/21 (33%)
		zf-H2C2_2	221..245	CDD:290200	10/23 (43%)
		C2H2 Zn finger	237..257	CDD:275368	10/19 (53%)
		COG5048	<245..451	CDD:227381	28/77 (36%)
		zf-H2C2_2	249..273	CDD:290200	13/25 (52%)
		C2H2 Zn finger	265..285	CDD:275368	7/21 (33%)
		zf-H2C2_2	280..302	CDD:290200	9/23 (39%)
		C2H2 Zn finger	293..313	CDD:275368	5/21 (24%)
		zf-H2C2_2	305..330	CDD:290200	4/13 (31%)
		C2H2 Zn finger	321..341	CDD:275368
		zf-H2C2_2	334..358	CDD:290200
		C2H2 Zn finger	349..369	CDD:275368
		zf-H2C2_2	362..386	CDD:290200
		C2H2 Zn finger	377..397	CDD:275368
		zf-H2C2_2	389..413	CDD:290200
		C2H2 Zn finger	405..425	CDD:275368
		zf-H2C2_2	418..442	CDD:290200
		C2H2 Zn finger	433..453	CDD:275368
		zf-H2C2_2	445..470	CDD:290200
		C2H2 Zn finger	461..480	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910