Protein Alignment pho and ZIC5

DIOPT Version :10

• Sequence 1: NP_524630.1
• Gene: pho / 43819
• FlyBaseID: FBgn0002521
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_149123.3
• Gene: ZIC5 / 85416
• HGNCID: 20322
• Length: 639
• Species: Homo sapiens
• Alignment Length: 121
• Identity: 54/121 - (44%)
• Similarity: 66/121 - (54%)
• Gaps: 10/121 - (8%)

  Fly   362 KGCNKHFRDSSAMRKHL---HTHGPR--VHVC--AEC---GKAFVESSKLKRHQLVHTGEKPFQC 416
            |.|:|.|.....:..|:   |..||.  .|||  .:|   ||.|....||..|..||||||||.|
Human   405 KPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPC 469

  Fly   417 TFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAK 472
            .|.||||.|:...||:.|.|.|||::||.|.||.|::|||.|::.|.|...|...|
Human   470 PFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	C2H2 Zn finger	359..381	CDD:275368	6/21 (29%)
		COG5048	<386..515	CDD:227381	46/92 (50%)
		C2H2 Zn finger	388..408	CDD:275368	8/24 (33%)
		zf-H2C2_2	401..426	CDD:463886	16/24 (67%)
		C2H2 Zn finger	416..438	CDD:275368	11/21 (52%)
		zf-H2C2_2	430..457	CDD:463886	15/26 (58%)
		C2H2 Zn finger	446..468	CDD:275368	10/21 (48%)
ZIC5	NP_149123.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..251
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..355
		zf_ZIC	366..429	CDD:436441	6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..409		2/3 (67%)
		COG5048	<405..551	CDD:227381	54/121 (45%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..491	CDD:275368	11/21 (52%)
		C2H2 Zn finger	499..521	CDD:275368	10/21 (48%)
		C2H2 Zn finger	529..551	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..568
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..639