DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and ZNF347

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	518	Identity:	121/518 - (23%)
Similarity:	186/518 - (35%)	Gaps:	151/518 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVL 108
            ::||:..|:      |..:|..|:.:.::..|...|::..   |....|         .|..||.
Human   309 QVIHTGEKR------YKCNECGKVFSRNSQLSQHQKIHTG---EKPYKC---------NECGKVF 355

  Fly   109 TNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKL-VHIKTMEGE----------- 161
            |    .|.......|:.....|:.      .|..||:.|....| :|..|..||
Human   356 T----QNSHLVRHRGIHTGEKPYK------CNECGKAFRARSSLAIHQATHSGEKPYKCNECGKV 410

  Fly   162 FS-----VTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTS------QQNKEYQ------ 209
            |:     ...|.....:..|..::         .|| .||:....:      ...|.|:
Human   411 FTQNSHLTNHWRIHTGEKPYKCNE---------CGK-AFGVRSSLAIHLVIHTGEKPYKCHECGK 465

  Fly   210 --KMESKFTNAQ---TLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPD 269
              :..|.....|   |.|.|:..:.   .....:...||:....|.         :.|:|....:
Human   466 VFRRNSHLARHQLIHTGEKPYKCNE---CGKAFRAHSNLTTHQVIH---------TGEKPYKCNE 518

  Fly   270 SSSIELVNETAAMTINNHRTLSNHTG-------NTGDLHALPSSVPFRIGLHEGQ----VNDCLS 323
            ...:...|...|    ||:.:  |||       ..|...::.||:.....:|.|:    .|:|..
Human   519 CGKVFTQNSHLA----NHQRI--HTGVKPYMCNECGKAFSVYSSLTTHQVIHTGEKPYKCNECGK 577

  Fly   324 TISQSTH--QDNTDSTG--------CGEM---------------------------------NLS 345
            ..:|::|  :.....||        ||::                                 ||:
Human   578 VFTQNSHLARHRGIHTGEKPYKCNECGKVFRHNSYLSRHQRIHTGEKPYKYNEYGKAFSEHSNLT 642

  Fly   346 EVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTH-GPRVHVCAECGKAFVESSKLKRHQLVHT 409
            ...|.:|.:|...|  ..|.|.|..:|.:.:|...| |.:.:.|.||||||.::|||.|||.|||
Human   643 THQVIHTGEKPYKC--NECGKVFTQNSHLARHRRVHTGGKPYQCNECGKAFSQTSKLARHQRVHT 705

  Fly   410 GEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAK 472
            ||||::|  ..|||.||:..:|.||..||||.:|:.|  :.|.|.|.|:::|..|...|...|
Human   706 GEKPYEC--NQCGKAFSVRSSLTTHQAIHTGKKPYKC--NECGKVFTQNSHLARHRGIHTGEK 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	12/73 (16%)
		C2H2 Zn finger	359..381	CDD:275368	6/21 (29%)
		COG5048	<386..515	CDD:227381	43/87 (49%)
		zf-C2H2	386..408	CDD:278523	13/21 (62%)
		C2H2 Zn finger	388..408	CDD:275368	13/19 (68%)
		zf-H2C2_2	401..426	CDD:290200	15/24 (63%)
		C2H2 Zn finger	416..438	CDD:275368	9/21 (43%)
		zf-H2C2_2	430..457	CDD:290200	12/26 (46%)
		C2H2 Zn finger	446..468	CDD:275368	7/21 (33%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368
		COG5048	273..728	CDD:227381	105/478 (22%)
		zf-H2C2_2	276..301	CDD:290200
		C2H2 Zn finger	292..312	CDD:275368	0/2 (0%)
		zf-H2C2_2	304..329	CDD:290200	6/25 (24%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		zf-H2C2_2	333..357	CDD:290200	8/39 (21%)
		C2H2 Zn finger	348..368	CDD:275368	7/32 (22%)
		zf-H2C2_2	360..383	CDD:290200	5/28 (18%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..413	CDD:290200	6/24 (25%)
		C2H2 Zn finger	404..424	CDD:275368	2/19 (11%)
		zf-H2C2_2	416..439	CDD:290200	4/32 (13%)
		C2H2 Zn finger	432..452	CDD:275368	4/29 (14%)
		zf-H2C2_2	444..469	CDD:290200	2/24 (8%)
		zf-C2H2	458..480	CDD:278523	3/21 (14%)
		C2H2 Zn finger	460..480	CDD:275368	2/19 (11%)
		zf-H2C2_2	472..495	CDD:290200	4/25 (16%)
		C2H2 Zn finger	488..508	CDD:275368	2/22 (9%)
		zf-H2C2_2	500..525	CDD:290200	5/33 (15%)
		C2H2 Zn finger	516..536	CDD:275368	4/25 (16%)
		zf-H2C2_2	528..552	CDD:290200	7/29 (24%)
		C2H2 Zn finger	544..564	CDD:275368	3/19 (16%)
		zf-H2C2_2	556..581	CDD:290200	5/24 (21%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		zf-H2C2_2	584..609	CDD:290200	5/24 (21%)
		C2H2 Zn finger	600..620	CDD:275368	2/19 (11%)
		C2H2 Zn finger	628..648	CDD:275368	3/19 (16%)
		zf-H2C2_2	640..665	CDD:290200	9/26 (35%)
		C2H2 Zn finger	656..676	CDD:275368	6/21 (29%)
		zf-H2C2_2	668..693	CDD:290200	10/24 (42%)
		C2H2 Zn finger	684..704	CDD:275368	13/19 (68%)
		zf-H2C2_2	697..720	CDD:290200	15/24 (63%)
		C2H2 Zn finger	712..732	CDD:275368	9/21 (43%)
		COG5048	723..>817	CDD:227381	17/44 (39%)
		zf-H2C2_2	724..749	CDD:290200	12/26 (46%)
		C2H2 Zn finger	740..760	CDD:275368	7/21 (33%)
		zf-H2C2_2	752..777	CDD:290200	4/13 (31%)
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000