DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pho and ZNF644

DIOPT Version :9

Sequence 1:NP_524630.1 Gene:pho / 43819 FlyBaseID:FBgn0002521 Length:520 Species:Drosophila melanogaster
Sequence 2:XP_005271314.1 Gene:ZNF644 / 84146 HGNCID:29222 Length:1368 Species:Homo sapiens


Alignment Length:461 Identity:101/461 - (21%)
Similarity:167/461 - (36%) Gaps:136/461 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASG----ISD 173
            ||..:.|..|           :|..|.||.|.:.:.:..|::        .|.:...|    :.|
Human   190 SNKKLPTSAS-----------VGCDIQNSVGSNIKSDGTLIN--------QVEVGEDGEDLLVKD 235

  Fly   174 DEYSGSDQIVGASDLLKGKEEFGIDGFTSQQ--NKEYQKMESKF--TNAQTLEMPHPISSVQIMD 234
            |   ..:.:.|.|.        |.|||.|:.  |.:.||...:|  ||.:|::...|.|.:    
Human   236 D---CVNTVTGISS--------GTDGFRSENDTNWDPQKEFIQFLMTNEETVDKAPPHSKI---- 285

  Fly   235 HLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELV-----NETAAMTINNHRTLSNHT 294
            .|.|:|   .::.::| :|...|...|.:...:|:.|.::.|     ||......:....||...
Human   286 GLEKKR---KRKMDVS-KITRYTEDCFSDSNCVPNKSKMQEVDFLEQNEELQAVDSQKYALSKVK 346

  Fly   295 GNTGDLHALPSSVPFR-IGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIA 358
            ..:.| ..|.|...|: :..:..:..:..|.:..||...||....|.|.: ||...:::.::...
Human   347 PESTD-EDLESVDAFQHLIYNPDKCGEESSPVHTSTFLSNTLKKKCEESD-SESPATFSTEEPSF 409

  Fly   359 CPHKGCNKHFRDSSAMRKHLHTH---------------GPRVHVCAECGKAFVESSKLKRHQLVH 408
            .|...||.:||:    :||||.|               .||.:.|.|||:.|.:.:.|.:|.::|
Human   410 YPCTKCNVNFRE----KKHLHRHMMYHLDGNSHFRHLNVPRPYACRECGRTFRDRNSLLKHMIIH 470

  Fly   409 TGEK------------------------PFQCTF-EGCGKRFSLDFNLRTHVRIHTGDRPFVCPF 448
            ...:                        | ||.| ..|.|.|.      .|.:.|..|:.:.|..
Human   471 QERRQKLMEEIRELKELQDEGRSARLQCP-QCVFGTNCPKTFV------QHAKTHEKDKRYYCCE 528

  Fly   449 DA-----------CNKKFAQSTNLKSHILTHAKAKRNT--------SISGKSGCSNAESNSQSED 494
            :.           |::..|....:|..::|...|:|.|        |:.|            |..
Human   529 ECNFMAVTENELECHRGIAHGAVVKCPMVTSDIAQRKTQKKTFMKDSVVG------------SSK 581

  Fly   495 TSANYV 500
            .||.|:
Human   582 KSATYI 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
phoNP_524630.1 Transpos_assoc <342..382 CDD:290671 12/54 (22%)
C2H2 Zn finger 359..381 CDD:275368 9/21 (43%)
COG5048 <386..515 CDD:227381 32/159 (20%)
zf-C2H2 386..408 CDD:278523 7/21 (33%)
C2H2 Zn finger 388..408 CDD:275368 7/19 (37%)
zf-H2C2_2 401..426 CDD:290200 9/49 (18%)
C2H2 Zn finger 416..438 CDD:275368 6/22 (27%)
zf-H2C2_2 430..457 CDD:290200 5/37 (14%)
C2H2 Zn finger 446..468 CDD:275368 4/32 (13%)
ZNF644XP_005271314.1 C2H2 Zn finger 412..432 CDD:275370 9/23 (39%)
RNAP_largest_subunit_N 438..>501 CDD:302765 11/63 (17%)
C2H2 Zn finger 450..470 CDD:275370 7/19 (37%)
C2H2 Zn finger 498..518 CDD:275368 8/26 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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