DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and SP1

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_612482.2	Gene:	SP1 / 6667	HGNCID:	11205	Length:	785	Species:	Homo sapiens

Alignment Length:	476	Identity:	102/476 - (21%)
Similarity:	177/476 - (37%)	Gaps:	116/476 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 TSKVLTNSLS-NNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMW 167
            :|...||:.| :....|...|:::    |.|.|::..||.|::.:      .:..::|..::.:.
Human   317 SSSFFTNANSYSTTTTTSNMGIMN----FTTSGSSGTNSQGQTPQ------RVSGLQGSDALNIQ 371

  Fly   168 ASGIS-------------DDEYSGSDQIVGASDLLKGKEEF------------------------ 195
            .:..|             .::.:...||:....|::|.:..
Human   372 QNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQ 436

  Fly   196 --------------------GIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKER 240
                                |.:|..|.|..:.|.::.:...|||:.:. |:..|.:
Human   437 NLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLA-PMQGVSL-------- 492

  Fly   241 GNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTG----DLH 301
            |..|..|.....|.|..::    |......::.:|.:.....|||     .:..|.:|    .:.
Human   493 GQTSSSNTTLTPIASAASI----PAGTVTVNAAQLSSMPGLQTIN-----LSALGTSGIQVHPIQ 548

  Fly   302 ALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGC-- 364
            .||.::....|.|..|:.  |.........|:|.....||.:......:....::.||....|
Human   549 GLPLAIANAPGDHGAQLG--LHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKD 611

  Fly   365 --NKHFRDSSAMRKHL-HTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFS 426
              .:...|....::|: |..|        |||.:.::|.|:.|...||||:||.||:..|||||:
Human   612 SEGRGSGDPGKKKQHICHIQG--------CGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFT 668

  Fly   427 LDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQ 491
            ....|:.|.|.|||::.|.||  .|.|:|.:|.:|..||.||...|....::...|....:|.:.
Human   669 RSDELQRHKRTHTGEKKFACP--ECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAG 731

  Fly   492 SEDT---------SANYVKVE 503
            ||.:         :.|.|.:|
Human   732 SEGSGTATPSALITTNMVAME 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	6/44 (14%)
		C2H2 Zn finger	359..381	CDD:275368	5/26 (19%)
		COG5048	<386..515	CDD:227381	45/127 (35%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..426	CDD:290200	14/24 (58%)
		C2H2 Zn finger	416..438	CDD:275368	10/21 (48%)
		zf-H2C2_2	430..457	CDD:290200	12/26 (46%)
		C2H2 Zn finger	446..468	CDD:275368	9/21 (43%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		Repressor domain	2..82
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..141
		Transactivation domain A (Gln-rich)	146..251
		Transactivation domain B (Gln-rich)	261..495		29/196 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..395		10/75 (13%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	462..470		2/7 (29%)
		Transactivation domain C (highly charged)	496..610		23/124 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..598		5/30 (17%)
		VZV IE62-binding	619..785		49/144 (34%)
		C2H2 Zn finger	628..650	CDD:275368	8/29 (28%)
		zf-H2C2_2	642..669	CDD:290200	15/26 (58%)
		C2H2 Zn finger	658..680	CDD:275368	10/21 (48%)
		zf-H2C2_2	672..695	CDD:290200	11/24 (46%)
		zf-C2H2	686..708	CDD:278523	10/23 (43%)
		C2H2 Zn finger	688..708	CDD:275368	9/21 (43%)
		Domain D	708..785		9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910