DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and SALL1

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_002959.2	Gene:	SALL1 / 6299	HGNCID:	10524	Length:	1324	Species:	Homo sapiens

Alignment Length:	485	Identity:	106/485 - (21%)
Similarity:	190/485 - (39%)	Gaps:	113/485 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TKVNQKMNEGNHYDLHRKNAFDRIIHS---ESKKGDNVI----NYNIHENDKI--KAADNIFSSK 77
            ||.|.|    .||.:||.....|:.||   ..||..|.:    :..:|...:|  ....:.:|..
Human   745 TKGNLK----THYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDSYSES 805

  Fly    78 LKMNPNMSYEMNINCFKNIGYGENQE------------TSKVLTNSLSNNDINTEESGVVDKNSP 130
            ::.:.....|.|.:...|.. .||.|            ::....:|||::.:..|.|.:....:.
Human   806 MESDTGSFDEKNFDDLDNFS-DENMEDCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQ 869

  Fly   131 FLTLGTTILNSNGKSRRWEQKLVHIK--TMEGEFSVTMWASGISDD---EYSGSDQIVGASDLLK 190
            .     .::|: |.:.:.:..|..::  ::||:. :|..:|.:..|   :.:||..|..::..::
Human   870 M-----KMINA-GLAEQLQASLKSVENGSIEGDV-LTNDSSSVGGDMESQSAGSPAISESTSSMQ 927

  Fly   191 ------GKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNI 249
                  ..:||  ....|.:.|..:.:.|:|.|..:   |.|::.           |.|...::.
Human   928 ALSPSNSTQEF--HKSPSIEEKPQRAVPSEFANGLS---PTPVNG-----------GALDLTSSH 976

  Fly   250 SERILSKTTLSFEEPILLP-------DSSSIELVNET----AAMTIN--NHR-------TLSNH- 293
            :|:|:.:.:|.    ||.|       .:::.::..:|    :|:.|:  :|.       |:.|.
Human   977 AEKIIKEDSLG----ILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRG 1037

  Fly   294 ---TGN------TGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVT- 348
               .||      |..:..|||           |:.:..|.:..:.:.....:.....:..:||.
Human  1038 FSTKGNLKQHMLTHQMRDLPS-----------QLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNG 1091

  Fly   349 ---VSYTNDKKIACPH--KGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVH 408
               ||..:.|.....|  .|.......|..:...|....|:.|.|..|||.|..||.|:.|:..|
Human  1092 FVHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTH 1156

  Fly   409 TGEKPFQCTFEGCGKRFSLDFNLRTHVRIH 438
            ||||||.||.  ||:.|:...||:.|:..|
Human  1157 TGEKPFACTI--CGRAFTTKGNLKVHMGTH 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	9/45 (20%)
		C2H2 Zn finger	359..381	CDD:275368	4/23 (17%)
		COG5048	<386..515	CDD:227381	26/53 (49%)
		zf-C2H2	386..408	CDD:278523	10/21 (48%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..426	CDD:290200	13/24 (54%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	4/9 (44%)
		C2H2 Zn finger	446..468	CDD:275368
SALL1	NP_002959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..336
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..488	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..646
		C2H2 Zn finger	708..728	CDD:275368
		zf-H2C2_2	720..745	CDD:290200	106/485 (22%)
		C2H2 Zn finger	736..756	CDD:275368	6/14 (43%)
		zf-C2H2	766..788	CDD:278523	5/21 (24%)
		C2H2 Zn finger	768..788	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..856		11/66 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..963		15/74 (20%)
		C2H2 Zn finger	1003..1023	CDD:275370	3/19 (16%)
		zf-H2C2_2	1015..1040	CDD:290200	5/24 (21%)
		zf-C2H2	1029..1051	CDD:278523	4/21 (19%)
		C2H2 Zn finger	1031..1051	CDD:275370	4/19 (21%)
		lambda-1	1064..>1155	CDD:212564	21/90 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1120		5/24 (21%)
		zf-C2H2	1134..1156	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1136..1156	CDD:275368	9/19 (47%)
		zf-H2C2_2	1148..1173	CDD:290200	14/26 (54%)
		C2H2 Zn finger	1164..1184	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030