DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and Sall1

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001357998.1	Gene:	Sall1 / 58198	MGIID:	1889585	Length:	1323	Species:	Mus musculus

Alignment Length:	491	Identity:	109/491 - (22%)
Similarity:	189/491 - (38%)	Gaps:	125/491 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TKVNQKMNEGNHYDLHRKNAFDRIIHS---ESKKGDNVI----NYNIHENDKI---KAADNIFSS 76
            ||.|.|    .||.:||.....|:.||   ..||..|.:    :..:|...:|   ...|| :..
Mouse   744 TKGNLK----THYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDN-YPE 803

  Fly    77 KLKMNPNMSYEMNINCFKNIGYGENQE------------TSKVLTNSLSNNDINTEESGVVDKNS 129
            .::.:.....|.|.:...|.. .||.|            ::....:|||::.:..|.|.:....:
Mouse   804 SMESDTGSFDEKNFDDLDNFS-DENMEECPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALEN 867

  Fly   130 PFLTLGTTILNSNGKSRRWEQKLVHIK--TMEGEFSVTMWASGISDD---EYSGSDQIVGASDLL 189
            ..     .::|: |.:.:.:..|..::  :|||:. :|..:|.:..|   :.:||..|..::..:
Mouse   868 QM-----KMINA-GLAEQLQASLKSVENGSMEGDV-LTNDSSSVGGDMESQSAGSPAISESTSSM 925

  Fly   190 KGKEEFGIDGFTSQQNKEYQK---MESK--------FTNAQTLEMPHPISSVQIMDHLIKERGNL 243
            :...       .|...:|:.|   ||.|        |.|..:   |.|::.           |.|
Mouse   926 QALS-------PSNSTQEFHKSPGMEEKPQRVGPGEFANGLS---PTPVNG-----------GAL 969

  Fly   244 SQENNISERILSKTTLSFEEPILLP-------DSSSIELVNET----AAMTIN--NHR------- 288
            ...::.:|:|:.:.:|.    ||.|       .:::.::..:|    :|:.|:  :|.
Mouse   970 DLTSSHAEKIIKEDSLG----ILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFIC 1030

  Fly   289 TLSNH----TGN------TGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMN 343
            |:.|.    .||      |..:..|||           |:.:..|.:..:.:.....:.....:.
Mouse  1031 TVCNRGFSTKGNLKQHMLTHQMRDLPS-----------QLFEPSSNLGPNQNSAVIPANSLSSLI 1084

  Fly   344 LSEVT----VSYTNDKKIACPH--KGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLK 402
            .:||.    ||..:.|.....|  :|.......|..:...|....|:.|.|..|||.|..||.|:
Mouse  1085 KTEVNGFVHVSPQDSKDAPTSHVPQGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQ 1149

  Fly   403 RHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIH 438
            .|:..|||||||.||.  ||:.|:...||:.|:..|
Mouse  1150 IHERTHTGEKPFACTI--CGRAFTTKGNLKVHMGTH 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	9/45 (20%)
		C2H2 Zn finger	359..381	CDD:275368	4/23 (17%)
		COG5048	<386..515	CDD:227381	26/53 (49%)
		zf-C2H2	386..408	CDD:278523	10/21 (48%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..426	CDD:290200	13/24 (54%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	4/9 (44%)
		C2H2 Zn finger	446..468	CDD:275368
Sall1	NP_001357998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..128
		SUF4-like	449..536	CDD:411020
		C2H2 Zn finger	452..473	CDD:411020
		C2H2 Zn finger	452..472	CDD:275368
		C2H2 Zn finger	480..500	CDD:411020
		C2H2 Zn finger	480..500	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..659
		COG5048	700..1168	CDD:227381	103/474 (22%)
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:404364	109/491 (22%)
		C2H2 Zn finger	735..755	CDD:275368	6/14 (43%)
		zf-C2H2	765..787	CDD:395048	5/21 (24%)
		C2H2 Zn finger	767..787	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..855		12/67 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..961		17/80 (21%)
		C2H2 Zn finger	1002..1022	CDD:275370	3/19 (16%)
		SUF4-like	1005..>1049	CDD:411020	8/43 (19%)
		C2H2 Zn finger	1005..1023	CDD:411020	3/17 (18%)
		zf-C2H2	1028..1050	CDD:395048	4/21 (19%)
		C2H2 Zn finger	1030..1050	CDD:275370	4/19 (21%)
		C2H2 Zn finger	1030..1049	CDD:411020	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1119		5/24 (21%)
		SUF4-like	1133..>1180	CDD:411020	24/48 (50%)
		C2H2 Zn finger	1135..1156	CDD:411020	9/20 (45%)
		C2H2 Zn finger	1135..1155	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1163..1183	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1163..1180	CDD:411020	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030