DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and SALL3

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_741996.2	Gene:	SALL3 / 27164	HGNCID:	10527	Length:	1300	Species:	Homo sapiens

Alignment Length:	529	Identity:	111/529 - (20%)
Similarity:	172/529 - (32%)	Gaps:	194/529 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IHSESKKGDNVINYNIHENDKIKAADNIFSSK----------------LKMNPN--MSYEMNINC 92
            ||..|..|:.....||        ..|.||:|                ::|||.  ..|..|:..
Human   437 IHLRSHTGERPFKCNI--------CGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPT 493

  Fly    93 FKNIGYGENQETSKVLTNSLSNNDI-NTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIK 156
            ...|.||.:....|.:|..|.:..: .|..:.|      .|.|..|:..::|
Human   494 CSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSV------GLQLPPTVPGAHG------------- 539

  Fly   157 TMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTL 221
                               |:.|.....||                                ::.
Human   540 -------------------YADSPSATPAS--------------------------------RSP 553

  Fly   222 EMPHPISSVQIMDHLIKERGNLSQ-----ENNIS------ERILSKTTLSFEEPILLPDSSS--- 272
            :.|.|.||         |..:||.     |:.:|      :.:|....|:..||:.||.:::
Human   554 QRPSPASS---------ECASLSPGLNHVESGVSATAESPQSLLGGPPLTKAEPVSLPCTNARAG 609

  Fly   273 ---IELVNETAAMTINNHRTLSNHTGNTGDLHALPS-SVPFRIGLHEGQVNDCLSTISQSTHQDN 333
               :......|..:::...|   ..|:.|    ||: |..|:.....|.:.|.:.|...|..|..
Human   610 DAPVGAQASAAPTSVDGAPT---SLGSPG----LPAVSEQFKAQFPFGGLLDSMQTSETSKLQQL 667

  Fly   334 TDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVES 398
            .::.                |||:..|::                         |..|.:.....
Human   668 VENI----------------DKKMTDPNQ-------------------------CVICHRVLSCQ 691

  Fly   399 SKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPF----VCPFDACNKKFAQST 459
            |.||.|...||||:||:|..  ||:.|:...||:||..:|....|.    .||.  |.|||..:.
Human   692 SALKMHYRTHTGERPFKCKI--CGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPI--CQKKFTNAV 752

  Fly   460 NLKSHILTHAKAK-RNTSI-SGKSGC---------SNAES-NSQSEDTSANYVK--VELQDSVTE 510
            .|:.||..|...: .||.: .|....         .|||: :|..:|...|.::  .||:|:.|:
Human   753 VLQQHIRMHMGGQIPNTPLPEGFQDAMDSELAYDDKNAETLSSYDDDMDENSMEDDAELKDAATD 817

  Fly   511 NHVPFVVYA 519
            ...|.:.||
Human   818 PAKPLLSYA 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	4/39 (10%)
		C2H2 Zn finger	359..381	CDD:275368	1/21 (5%)
		COG5048	<386..515	CDD:227381	45/146 (31%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..426	CDD:290200	12/24 (50%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	12/30 (40%)
		C2H2 Zn finger	446..468	CDD:275368	9/21 (43%)
SALL3	NP_741996.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..352
		COG5048	412..>734	CDD:227381	84/433 (19%)
		C2H2 Zn finger	422..442	CDD:275368	2/4 (50%)
		C2H2 Zn finger	450..470	CDD:275368	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..633		26/191 (14%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		zf-H2C2_2	693..718	CDD:316026	13/26 (50%)
		C2H2 Zn finger	709..729	CDD:275368	8/21 (38%)
		zf-C2H2	739..761	CDD:306579	9/23 (39%)
		C2H2 Zn finger	741..761	CDD:275368	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..955
		C2H2 Zn finger	979..999	CDD:275368
		C2H2 Zn finger	1007..1027	CDD:275368
		zf-C2H2	1113..1135	CDD:306579
		C2H2 Zn finger	1115..1135	CDD:275368
		zf-H2C2_2	1127..1152	CDD:316026
		C2H2 Zn finger	1143..1163	CDD:275368
		zf-C2H2	1143..1163	CDD:306579
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1259..1279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030