DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and Zim1

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_035899.4	Gene:	Zim1 / 22776	MGIID:	1341879	Length:	579	Species:	Mus musculus

Alignment Length:	344	Identity:	97/344 - (28%)
Similarity:	144/344 - (41%)	Gaps:	69/344 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 VGASDLLKGKEEFGIDGFTSQQNK---------EYQKMESKFTNAQTLEMPHPISSVQIMDHLIK 238
            |..||...||:. |.:...::..|         |.||...:...:|:|.......|        .
Mouse   126 VSRSDTSAGKKT-GDNSTKAEIRKPDNSKTTSLEKQKAADQGRGSQSLRAEKTSKS--------D 181

  Fly   239 ERGNLSQEN--NISERILSKTTL--SFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGD 299
            :|.:.::|.  :.|....|||::  :.|....:|.:||    .:|:|.|.......|....:..|
Mouse   182 DRPSQNKEKCASTSTTEASKTSIPGNKENESAIPGTSS----GQTSAATTTPQSAPSEKPTSGKD 242

  Fly   300 LHALPSSV----------PFRIGLHEGQVNDCLSTISQSTH--QDNTDSTG--------CGE--M 342
            :...|.::          |.|.|.:..:..:|..|.:|:.|  :.....||        ||:  .
Mouse   243 VEGKPQTMRSSSTNPKRKPARQGKNHFKCKECGKTFNQTLHLVEHERIHTGEKPHKCDTCGKSFR 307

  Fly   343 NLSEVTVSY---TNDKKIACPHKGCNKHFRDSSAMRKHLHTH-GPRVHVCAECGKAFVESSKLKR 403
            :||.....|   |..:...|  |.|.|.|..||.:..|...| |.:...|.||||.|.:|:||.|
Mouse   308 HLSYFLTHYRIHTGVRPYKC--KECGKAFNSSSTLNNHCRIHSGEKPFKCDECGKTFKQSTKLTR 370

  Fly   404 HQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTH 468
            ||.:||||||::|  ..|.|.|....:||.|.|||||::|:.|  ..|.|.|..:::|..|...|
Mouse   371 HQRIHTGEKPYKC--GECNKCFGRSSSLREHKRIHTGEKPYCC--QVCGKTFRVNSHLSEHQRLH 431

  Fly   469 AKAK-----------RNTS 476
            .|.|           ||:|
Mouse   432 LKVKPYKCDKCGKHFRNSS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	13/43 (30%)
		C2H2 Zn finger	359..381	CDD:275368	8/21 (38%)
		COG5048	<386..515	CDD:227381	43/102 (42%)
		zf-C2H2	386..408	CDD:278523	12/21 (57%)
		C2H2 Zn finger	388..408	CDD:275368	12/19 (63%)
		zf-H2C2_2	401..426	CDD:290200	13/24 (54%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	13/26 (50%)
		C2H2 Zn finger	446..468	CDD:275368	6/21 (29%)
Zim1	NP_035899.4	KRAB	50..105	CDD:214630
		PRK13335	137..>269	CDD:139494	27/144 (19%)
		COG5048	<226..427	CDD:227381	65/206 (32%)
		C2H2 Zn finger	271..291	CDD:275368	4/19 (21%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..347	CDD:275368	8/21 (38%)
		C2H2 Zn finger	355..375	CDD:275368	12/19 (63%)
		C2H2 Zn finger	383..403	CDD:275368	8/21 (38%)
		C2H2 Zn finger	411..431	CDD:275368	6/21 (29%)
		zf-C2H2	437..459	CDD:333835	3/14 (21%)
		C2H2 Zn finger	439..459	CDD:275368	3/12 (25%)
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	495..515	CDD:275368
		zf-C2H2	521..543	CDD:333835
		C2H2 Zn finger	523..543	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000