DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pho and Zfp37

DIOPT Version :9

Sequence 1:NP_524630.1 Gene:pho / 43819 FlyBaseID:FBgn0002521 Length:520 Species:Drosophila melanogaster
Sequence 2:NP_001277279.1 Gene:Zfp37 / 22696 MGIID:99181 Length:594 Species:Mus musculus


Alignment Length:466 Identity:113/466 - (24%)
Similarity:175/466 - (37%) Gaps:115/466 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 NCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPF--------LTLGTTI-LNSNGKSR 146
            ||......| ||:..:.:.:.|...:   ..||...|.||.        .|.||:. |..:.:.|
Mouse    35 NCSNPASMG-NQDPKQDIVSVLEEEE---PSSGKGKKASPSSLKKIARPKTAGTSAKLQQDDEHR 95

  Fly   147 RWEQ----KLVHIKTMEGEFSVTMWAS--GISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQN 205
            ..:|    ||....|:..:.|.:..:|  |:.:::...|........|||....    |..|.||
Mouse    96 EEKQKSQSKLTKEVTLRKKSSNSKKSSEYGLLENKSLHSKHTPSEKKLLKSSSR----GKNSNQN 156

  Fly   206 KEYQKMESKFTNAQTLEMPHPISSV------------QIMDHLIKERGNLSQENNISERILSKTT 258
            .:..|.:....|.....:.|..|.|            ::.::.:.::|:.:|.:...|::...:.
Mouse   157 SDSLKKKPDTANDHRKSLSHSASDVNKDEIPTRKKCDKLPNNKLSDKGDKNQTSKKCEKVCRHSA 221

  Fly   259 LSFEE------------------PILLPDSSSIELVNETAAM------TINNHRTLS-------- 291
            ...:|                  |...|.|......|....:      .:::.||.:        
Mouse   222 SHTKEDKIQTGEKRKSHCRTPSKPEKAPGSGKPYECNHCGKVLSHKQGLLDHQRTHTGEKPYECN 286

  Fly   292 -----------------NHTGNT-----------GDLHALPSSVPFRIGLHEGQVNDCLSTISQS 328
                             .|||..           |..|||...:....|....:.|:|..|...|
Mouse   287 ECGIAFSQKSHLVVHQRTHTGEKPYECEQCGKAHGHKHALTDHLRIHTGEKPYKCNECGKTFRHS 351

  Fly   329 THQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTH-GPRVHVCAECG 392
            :             ||.:...|:|.:|...|  |.|.|.||.:|::.:|:.|| |...:.|.|||
Mouse   352 S-------------NLMQHLRSHTGEKPYEC--KECGKSFRYNSSLTEHVRTHTGEIPYECNECG 401

  Fly   393 KAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQ 457
            |||...|.|.:|..:|||||||:|  ..|||.||...:|..|.|.||.::|:.|  |.|.|.|..
Mouse   402 KAFKYGSSLTKHMRIHTGEKPFEC--NECGKTFSKKSHLVIHQRTHTKEKPYKC--DECGKAFGH 462

  Fly   458 STNLKSHILTH 468
            |::|..|:.||
Mouse   463 SSSLTYHMRTH 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
phoNP_524630.1 Transpos_assoc <342..382 CDD:290671 15/40 (38%)
C2H2 Zn finger 359..381 CDD:275368 8/21 (38%)
COG5048 <386..515 CDD:227381 39/83 (47%)
zf-C2H2 386..408 CDD:278523 10/21 (48%)
C2H2 Zn finger 388..408 CDD:275368 10/19 (53%)
zf-H2C2_2 401..426 CDD:290200 13/24 (54%)
C2H2 Zn finger 416..438 CDD:275368 9/21 (43%)
zf-H2C2_2 430..457 CDD:290200 11/26 (42%)
C2H2 Zn finger 446..468 CDD:275368 8/21 (38%)
Zfp37NP_001277279.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..253 43/225 (19%)
KRAB 15..62 CDD:214630 6/30 (20%)
KRAB_A-box <15..42 CDD:143639 2/6 (33%)
COG5048 124..486 CDD:227381 91/373 (24%)
C2H2 Zn finger 257..277 CDD:275368 2/19 (11%)
zf-H2C2_2 270..294 CDD:290200 2/23 (9%)
C2H2 Zn finger 285..305 CDD:275368 0/19 (0%)
zf-H2C2_2 297..319 CDD:290200 3/21 (14%)
C2H2 Zn finger 313..333 CDD:275368 4/19 (21%)
zf-H2C2_2 325..350 CDD:290200 6/24 (25%)
C2H2 Zn finger 341..361 CDD:275368 6/32 (19%)
zf-H2C2_2 353..378 CDD:290200 10/26 (38%)
C2H2 Zn finger 369..389 CDD:275368 8/21 (38%)
zf-H2C2_2 381..406 CDD:290200 11/24 (46%)
C2H2 Zn finger 397..417 CDD:275368 10/19 (53%)
zf-H2C2_2 409..433 CDD:290200 13/25 (52%)
C2H2 Zn finger 425..445 CDD:275368 9/21 (43%)
zf-H2C2_2 437..460 CDD:290200 10/24 (42%)
zf-C2H2 451..473 CDD:278523 8/23 (35%)
C2H2 Zn finger 453..473 CDD:275368 8/21 (38%)
zf-H2C2_2 465..490 CDD:290200 4/9 (44%)
C2H2 Zn finger 481..501 CDD:275368
zf-H2C2_2 494..518 CDD:290200
C2H2 Zn finger 509..529 CDD:275368
zf-H2C2_2 521..545 CDD:290200
C2H2 Zn finger 537..557 CDD:275368
zf-H2C2_2 550..574 CDD:290200
C2H2 Zn finger 565..585 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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