DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and Sall3

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001356062.1	Gene:	Sall3 / 20689	MGIID:	109295	Length:	1320	Species:	Mus musculus

Alignment Length:	531	Identity:	106/531 - (19%)
Similarity:	164/531 - (30%)	Gaps:	192/531 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IHSESKKGDNVINYNIHENDKIKAADNIFSSK----------------LKMNPN--MSYEMNINC 92
            ||..|..|:.....||        ..|.||:|                ::|||.  ..|..|:..
Mouse   444 IHLRSHTGERPFKCNI--------CGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPT 500

  Fly    93 FKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKT 157
            ...|.||.:....|.:|..|.:..:.......|....|....||
Mouse   501 CSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGT--------------------- 544

  Fly   158 MEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLE 222
                            ..|:.|..|...|                                ::.:
Mouse   545 ----------------HNYTDSPSITPVS--------------------------------RSPQ 561

  Fly   223 MPHPISS--VQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSS-----------IE 274
            .|.|.||  ..:...|......::......:.:|...:|:..||:.||.:|:           :.
Mouse   562 RPSPASSECTSLSPGLNNTESGITVRPESPQPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQVS 626

  Fly   275 LVNETAAMTINNHRTLSNHTGNTGDLHALPS-SVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTG 338
            .:..:||..:.:....|  .|:.|    ||: |..|:.....|.:.|.:.|...|..|...::.
Mouse   627 GLPTSAATAVTDSACTS--LGSPG----LPAVSDQFKAQFPFGGLLDSMQTSETSKLQQLVENI- 684

  Fly   339 CGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKR 403
                           |||:..|::                         |..|.:.....|.||.
Mouse   685 ---------------DKKMTDPNQ-------------------------CVICHRVLSCQSALKM 709

  Fly   404 HQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPF----VCPFDACNKKFAQSTNLKSH 464
            |...||||:||:|..  ||:.|:...||:||..:|....|.    .||.  |.|||..:..|:.|
Mouse   710 HYRTHTGERPFKCKI--CGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPI--CQKKFTNAVVLQQH 770

  Fly   465 ILTHAKAK-RNTSI-SGKSGC---------SNAES----------NSQSEDTSANYVKVELQDSV 508
            |..|...: .||.: .|....         .|||:          ||..||:       ||:|:.
Mouse   771 IRMHMGGQIPNTPLPEGLQEAMDADLPFDEKNAETLSSFDDDIDENSMEEDS-------ELKDTA 828

  Fly   509 TENHVPFVVYA 519
            :::..|.:.|:
Mouse   829 SDSSKPLLSYS 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	4/39 (10%)
		C2H2 Zn finger	359..381	CDD:275368	1/21 (5%)
		COG5048	<386..515	CDD:227381	45/153 (29%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..426	CDD:290200	12/24 (50%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	12/30 (40%)
		C2H2 Zn finger	446..468	CDD:275368	9/21 (43%)
Sall3	NP_001356062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..166
		PHA03247	<242..384	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..367
		COG5048	419..>727	CDD:227381	73/408 (18%)
		C2H2 Zn finger	429..449	CDD:275368	2/4 (50%)
		zf-H2C2_2	441..466	CDD:338759	8/29 (28%)
		C2H2 Zn finger	457..477	CDD:275368	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..623		19/157 (12%)
		C2H2 Zn finger	694..714	CDD:275368	6/19 (32%)
		zf-H2C2_2	706..731	CDD:338759	13/26 (50%)
		COG5048	718..1168	CDD:227381	37/133 (28%)
		C2H2 Zn finger	722..742	CDD:275368	8/21 (38%)
		C2H2 Zn finger	754..774	CDD:275368	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..846		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..972
		C2H2 Zn finger	999..1019	CDD:275368
		C2H2 Zn finger	1027..1047	CDD:275368
		C2H2 Zn finger	1135..1155	CDD:275368
		C2H2 Zn finger	1163..1183	CDD:275368
		zf-C2H2	1163..1183	CDD:333835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030