Protein Alignment pho and EGR3

DIOPT Version :10

• Sequence 1: NP_524630.1
• Gene: pho / 43819
• FlyBaseID: FBgn0002521
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_005273482.1
• Gene: EGR3 / 1960
• HGNCID: 3240
• Length: 442
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 116/471 - (24%)
• Similarity: 165/471 - (35%)
• Gaps: 153/471 - (32%)

  Fly   122 SGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGS----DQI 182
            :||.:..:||  .|.|:|.|..|:                            .|.|||    .:.
Human     7 AGVGEGRAPF--EGDTLLRSEDKA----------------------------SERSGSATREQRA 41

  Fly   183 VGASDLLKGKEEFGIDGFTS-QQNKEYQKMESKF-------TNAQTLEMPHPISSVQ-------- 231
            .|||   .|:|..|:...|. ::..|...:||:.       |......:|.|....|
Human    42 WGAS---PGRERRGVLERTGPREEAELCAVESESPARSGSETTCSCSYLPAPPREEQQCFSRARA 103

  Fly   232 -----IMD-HLIKERGN--LSQENNISERILSKTT-----LSFEEP--------ILL-------- 267
                 :|| .|..|:.|  ||...:......:||.     .:|:.|        |.|
Human   104 CVCENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGV 168

  Fly   268 -PDSSSIELVNETAAMT------INNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTI 325
             |.|.::.....||:|.      :...........|.|||::.|      :..|:.|.|..|:
Human   169 PPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEP------VSFHDPQGNPGLA-- 225

  Fly   326 SQSTHQDNTDSTGCGEMNLSEVTVSYT-----NDKKIACPHK---GCN---------------KH 367
              .:.||...:....:.||..:...|.     ||......||   |.:               |.
Human   226 --YSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKA 288

  Fly   368 FRDS----------------SAMRKHLHTHGP-------RVHVC-AE-CGKAFVESSKLKRHQLV 407
            |:|.                ..:|...:.:.|       |.|.| || |.:.|..|.:|.||..:
Human   289 FKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRI 353

  Fly   408 HTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAK 472
            |||.|||||..  |.:.||...:|.||:|.|||::||.|.|  |.:|||:|...|.|...|.|.|
Human   354 HTGHKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFACEF--CGRKFARSDERKRHAKIHLKQK 414

  Fly   473 RNTSISGKSGCSNAES 488
            ...  :.|.|..:|.|
Human   415 EKK--AEKGGAPSASS 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	C2H2 Zn finger	359..381	CDD:275368	7/55 (13%)
		COG5048	<386..515	CDD:227381	46/105 (44%)
		C2H2 Zn finger	388..408	CDD:275368	9/21 (43%)
		zf-H2C2_2	401..426	CDD:463886	12/24 (50%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:463886	14/26 (54%)
		C2H2 Zn finger	446..468	CDD:275368	9/21 (43%)
EGR3	XP_005273482.1	DUF3446	142..228	CDD:463400	18/95 (19%)
		SFP1	<254..408	CDD:227516	50/157 (32%)
		C2H2 Zn finger	332..354	CDD:275368	9/21 (43%)
		COG5048	358..>431	CDD:227381	33/77 (43%)
		C2H2 Zn finger	362..382	CDD:275368	8/21 (38%)
		C2H2 Zn finger	390..410	CDD:275368	9/21 (43%)