DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and sem-4

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_491997.1	Gene:	sem-4 / 172435	WormBaseID:	WBGene00004773	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	81/354 - (22%)
Similarity:	125/354 - (35%)	Gaps:	69/354 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 QQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILL 267
            |.:::....:.:|.||..|.:           |:.:.|.:|:|...:   :.:.||...:....:
Worm   408 QASQQCPICQQRFLNAGELAV-----------HITEHRNSLTQPPRV---MPTPTTTRVQTFPFV 458

  Fly   268 PDSSSIELVNETAAMT-INNHRTLSNHTGNTGDLHALPSSV---------PFRIGLHEGQVNDCL 322
            |..::...:|.|...| .|....||....|....:...|||         |....|.....:|.
Worm   459 PFFTTPPSLNATDMSTQFNLANILSAQLKNDSSPNTDTSSVEEKITRDDPPKMASLSPSNSSDS- 522

  Fly   323 STISQSTHQDNTDST-------GCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHT 380
               |.|..||..:|:       ...|..:.|..||.|.:.|...|.....|.:.::       ..
Worm   523 ---SSSVRQDILESSEFEEKLKKLEEPPILEQQVSTTPNPKNENPLLAMQKMWAET-------EP 577

  Fly   381 HGPR------VHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHT 439
            ..||      .|.|..|.|.|..||.|:.|...|||:|||:|  :.||:.|:...||:.|:..|:
Worm   578 PPPRQMPVLSKHQCGVCFKHFSSSSALQIHMRTHTGDKPFKC--DMCGRAFTTRGNLKVHMGTHS 640

  Fly   440 --------GDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSG-----------CSN 485
                    |.|.|........|...||..|.:.....|........:|.||           ||.
Worm   641 WQQSPSRRGRRIFDVASSVTEKPMLQSPILPTSGAPGASPLAMLGPNGLSGLEMMMMLWRTVCSV 705

  Fly   486 AESNSQSEDTSANYVKVELQDSVTENHVP 514
            .:...||.:....::|..|.:..:....|
Worm   706 CQKVCQSPNELEQHLKEHLNNGSSAAPTP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	7/39 (18%)
		C2H2 Zn finger	359..381	CDD:275368	2/21 (10%)
		COG5048	<386..515	CDD:227381	41/148 (28%)
		zf-C2H2	386..408	CDD:278523	9/21 (43%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	401..426	CDD:290200	11/24 (46%)
		C2H2 Zn finger	416..438	CDD:275368	7/21 (33%)
		zf-H2C2_2	430..457	CDD:290200	8/34 (24%)
		C2H2 Zn finger	446..468	CDD:275368	4/21 (19%)
sem-4	NP_491997.1	C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		lambda-1	553..>610	CDD:212564	17/63 (27%)
		zf-C2H2	589..611	CDD:278523	9/21 (43%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
		zf-H2C2_2	603..628	CDD:290200	12/26 (46%)
		C2H2 Zn finger	619..639	CDD:275368	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030