DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and ZFP42

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001291287.1	Gene:	ZFP42 / 132625	HGNCID:	30949	Length:	310	Species:	Homo sapiens

Alignment Length:	319	Identity:	120/319 - (37%)
Similarity:	155/319 - (48%)	Gaps:	89/319 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 YSGSDQIVGASDLLKGKEEFGIDGFTSQ---------QNKEY------QKMESKFTNAQTLEMPH 225
            |....|.:|..|......|..|.|..||         ::.||      |::..|...|.:||
Human    56 YEPGPQALGGDDFSDCYIECVIRGEFSQPILEEDSLFESLEYLKKGSEQQLSQKVFEASSLE--- 117

  Fly   226 PISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPIL---LPDSSSIELVNETAAMTINNH 287
              .|::.|...:|:        .:.::|:.:.:|.:.|.:.   ||
Human   118 --CSLEYMKKGVKK--------ELPQKIVGENSLEYSEYMTGKKLP------------------- 153

  Fly   288 RTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSE--VTVS 350
                            |..:|   |:                  |.:|.....|....:  :...
Human   154 ----------------PGGIP---GI------------------DLSDPKQLAEFARKKPPINKE 181

  Fly   351 YTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQ 415
            |.:...||||..||.:..|:.:|:||||..||||.|||||||||||||||||||.|||||||||:
Human   182 YDSLSAIACPQSGCTRKLRNRAALRKHLLIHGPRDHVCAECGKAFVESSKLKRHFLVHTGEKPFR 246

  Fly   416 CTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRN 474
            |||||||||||||||||||||||||::.|||||..||::|.||.|||:||||||...:|
Human   247 CTFEGCGKRFSLDFNLRTHVRIHTGEKRFVCPFQGCNRRFIQSNNLKAHILTHANTNKN 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	13/41 (32%)
		C2H2 Zn finger	359..381	CDD:275368	10/21 (48%)
		COG5048	<386..515	CDD:227381	73/89 (82%)
		zf-C2H2	386..408	CDD:278523	20/21 (95%)
		C2H2 Zn finger	388..408	CDD:275368	18/19 (95%)
		zf-H2C2_2	401..426	CDD:290200	22/24 (92%)
		C2H2 Zn finger	416..438	CDD:275368	21/21 (100%)
		zf-H2C2_2	430..457	CDD:290200	19/26 (73%)
		C2H2 Zn finger	446..468	CDD:275368	14/21 (67%)
ZFP42	NP_001291287.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C2H2 Zn finger	190..212	CDD:275368	10/21 (48%)
		COG5048	214..>307	CDD:227381	75/92 (82%)
		C2H2 Zn finger	219..239	CDD:275368	18/19 (95%)
		zf-H2C2_2	232..257	CDD:290200	22/24 (92%)
		C2H2 Zn finger	247..269	CDD:275368	21/21 (100%)
		zf-H2C2_2	261..288	CDD:290200	19/26 (73%)
		C2H2 Zn finger	277..299	CDD:275368	14/21 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D362296at33208
OrthoFinder	1	1.000	-	-		FOG0003443
OrthoInspector	1	1.000	-	-		otm42215
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.980