DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pho and sall1

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001090646.1	Gene:	sall1 / 100036618	XenbaseID:	XB-GENE-491393	Length:	1330	Species:	Xenopus tropicalis

Alignment Length:	443	Identity:	92/443 - (20%)
Similarity:	149/443 - (33%)	Gaps:	142/443 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 HIKT-MEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKE---------- 207
            ||:. |.|:...|..|....|...|.:    |:.|   .|....:|.| |.:|.|
Frog   790 HIRMHMGGQIPNTPIAESYPDSMESDT----GSFD---EKTIDDLDNF-SDENMEDCPDSSVPDT 846

  Fly   208 YQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSS 272
            .:.:::...:..:..:|..:||:..:::.:| ..|......:...:.|....|.|...:..||||
Frog   847 PKSVDASQDSLSSSPLPPEVSSITALENQMK-LINAGLAEQLQASLKSTENGSIEGDGMTNDSSS 910

  Fly   273 I--ELVNETAAMTINNHRTLSNH----TGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQ 331
            :  ::.:::|.....:..|.|.|    :.:|.|....|::        :.:::..|| :..::..
Frog   911 LGGDMESQSAGSPAASESTYSMHALSPSNSTNDYLKSPNT--------DEKIHRALS-LDPTSGL 966

  Fly   332 DNTDSTGCGEMNLSEVTVSYTNDKKIACPHKG------------------CNKHFRDSSAMRKHL 378
            ..|.:.| |.::|:    |...||.|...|.|                  |.|.|...||:..|.
Frog   967 SPTPANG-GALDLT----SSNTDKVIKDEHLGVLFPFRERGKYKNTICDICGKTFACQSALDIHY 1026

  Fly   379 HTH-GPRVHVCAECGKAFVESSKLKRHQLVH---------------------------------- 408
            .:| ..|..:|..|.:.|.....||:|.|.|
Frog  1027 RSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSSMTPTPTVPSTPTNPLATII 1091

  Fly   409 ------------------------TGEKPFQCT-----------------FEGCGKRFSLDFNLR 432
                                    :|..|...|                 ...|||.||....|:
Frog  1092 KTEFNGFMHGSSQDIKEQPTNIVSSGSLPSSATSPVLLPALARRTPKQHYCNACGKSFSSSSALQ 1156

  Fly   433 THVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTH------AKAKRNTSISG 479
            .|.|.|||::||.|..  |.:.|....|||.|:.||      |:..|..|:.|
Frog  1157 IHERTHTGEKPFACTI--CGRAFTTKGNLKVHMGTHMWNSTPARRGRRLSVDG 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	14/58 (24%)
		C2H2 Zn finger	359..381	CDD:275368	8/39 (21%)
		COG5048	<386..515	CDD:227381	37/175 (21%)
		zf-C2H2	386..408	CDD:278523	7/21 (33%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..426	CDD:290200	11/99 (11%)
		C2H2 Zn finger	416..438	CDD:275368	9/38 (24%)
		zf-H2C2_2	430..457	CDD:290200	11/26 (42%)
		C2H2 Zn finger	446..468	CDD:275368	7/21 (33%)
sall1	NP_001090646.1	PHA03247	<278..683	CDD:223021
		PRK10856	<326..>438	CDD:236776
		SUF4-like	461..543	CDD:411020
		C2H2 Zn finger	464..485	CDD:411020
		C2H2 Zn finger	464..484	CDD:275368
		C2H2 Zn finger	492..512	CDD:411020
		C2H2 Zn finger	492..512	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	726..751	CDD:404364
		C2H2 Zn finger	742..762	CDD:275368
		zf-C2H2	772..794	CDD:395048	2/3 (67%)
		C2H2 Zn finger	774..794	CDD:275368	2/3 (67%)
		C2H2 Zn finger	1009..1029	CDD:275370	6/19 (32%)
		SUF4-like	1012..>1056	CDD:411020	14/43 (33%)
		C2H2 Zn finger	1012..1030	CDD:411020	6/17 (35%)
		zf-C2H2	1035..1057	CDD:395048	7/21 (33%)
		C2H2 Zn finger	1037..1057	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1037..1056	CDD:411020	6/18 (33%)
		SUF4-like	1140..>1187	CDD:411020	19/48 (40%)
		C2H2 Zn finger	1142..1163	CDD:411020	8/20 (40%)
		C2H2 Zn finger	1142..1162	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1170..1190	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1170..1187	CDD:411020	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030