DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED26 and Med26

DIOPT Version :9

Sequence 1:	NP_651936.1	Gene:	MED26 / 43816	FlyBaseID:	FBgn0039923	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_081761.2	Gene:	Med26 / 70625	MGIID:	1917875	Length:	588	Species:	Mus musculus

Alignment Length:	705	Identity:	150/705 - (21%)
Similarity:	240/705 - (34%)	Gaps:	254/705 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QELTTHLSQALDQNYDVVNMDAVLCVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRA 71
            |::...|.||:|...::.||.|||.||.:||...||||.||.|||.|.||.:|::||||.||:||
Mouse     9 QQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRA 73

  Fly    72 KSLLKKWREMV--------------GIQQTATENLAH-----------PSQISSSQPALDLVKSP 111
            |.||:.|::::              |...:|... ||           |..|...:...|:.:.|
Mouse    74 KRLLRSWQKLIEPVHQNEVALRALAGAAGSANGG-AHNCRPEMGVAGAPKSIHDLKNRNDIQRLP 137

  Fly   112 ---------------------------ITSFITEPIAPSQQIVSDLHSNIDSAEP-----PLSGE 144
                                       ::....:|:.|:   .|.|.:|..|..|     ||.|.
Mouse   138 GQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPN---ASPLPTNGISGSPESLPSPLDGS 199

  Fly   145 -HTLLHPNFSNLVNSIKDSDRHE-NIAITTLHTHKDRRHSHSIRSCHVASPQPIVIDHSVNSVIN 207
             |  |.|:.|.|..|  |:::|. .|.:..:   :.|..|..:..    .|.|.:
Mouse   200 GH--LGPDGSRLEPS--DNEKHSTKIPVNAV---RPRPSSPGLGK----PPVPCL---------- 243

  Fly   208 LTDDSTVKINEASVVIDIASDS-----DENDNNGSLNPKKL------------------------ 243
              .....::.:    :|.|.:|     ....:..|.:|:..
Mouse   244 --QTKAAQLQQ----LDRADESPGPPYPRGSSRCSFSPRNSRHEGSFSRHRSSYIPKGQVSSPSP 302

  Fly   244 ------NSIVPAPLPI--PSTPSSRQRKLKKEKRS-----KEREGQVATNTRFGAKASDGFQQAA 295
                  |:.||:|||:  |.||..|:::|.....|     ::.||.....   |.....||
Mouse   303 WPQPPDNTQVPSPLPLAQPPTPPVRRQELLPNAESPVHWPEQSEGHPRLT---GPACRAGF---- 360

  Fly   296 LTTDSEIFSLSNSSMSSIVSGDATS---SYSQNKSRLNSNELTFTGRFKAVDHLFRSTESGKHKI 357
                        |..||....||||   |.|:.|.|....:.|..
Mouse   361 ------------SPDSSKADSDATSSGGSDSKKKKRYRPRDYTVN-------------------- 393

  Fly   358 DEYSAYDSNASCSRLSPSTVDEVKKAEHLFDAQLTNTTANQI-PMSAVSIGYESNTRHEYLESDS 421
                 .|...:.:.:.|..:.|.|..   ||..     ..|| |:          |:.|.:.:||
Mouse   394 -----LDGQVAEAGVKPVRLKERKLT---FDPM-----TRQIRPL----------TQKEPVRADS 435

  Fly   422 P---SQIPKRRGRKKGSKGVDALIAKESSSLSQQIFFGGSTVKKVKTTKEL------FNEIQSRK 477
            |   .|:|:                   :.|.||         :||.:.:.      :.|:...:
Mouse   436 PVPTEQLPR-------------------TELEQQ---------EVKASLQSPFEQTNWKELSRNE 472

  Fly   478 LSVSMQSSASNLSNSSTNRDLPSH---TTFPRQTSSCSDTSMNSPHILETLSGSAIFASKIDDLG 539
            :..|..|..|:|.:||..:...:|   ..:.:|..| |......||:|..|...........::.
Mouse   473 IIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEES-SRQGARQPHVLLPLPTPTDLPGLTREVT 536

  Fly   540 NTDSDTVTSDPSHDSNKSQEIK-------ECTSLDSNSNSIQSLPLANNRENLIP 587
            ..|.|.:.:......|..::.:       :|.|||.:.:        :.|.|::|
Mouse   537 QDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGD--------DGRLNILP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED26	NP_651936.1	Med26	32..82	CDD:285873	29/49 (59%)
Med26	NP_081761.2	TFS2N	12..86	CDD:197766	38/73 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..393		61/329 (19%)
		Med26_M	178..405	CDD:292322	56/297 (19%)
		Med26_C	407..586	CDD:292321	44/232 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..441		11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837027
Domainoid	1	1.000	60	1.000	Domainoid score	I10589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009766
OrthoInspector	1	1.000	-	-		oto92362
orthoMCL	1	0.900	-	-		OOG6_114447
Panther	1	1.100	-	-	LDO	PTHR15201
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4647
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.920