back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and CD22

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	565	Identity:	122/565 - (21%)
Similarity:	194/565 - (34%)	Gaps:	148/565 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  8297 KYKIHDAVFDRRQAAPRFVIR--PSSQFCYEGQSVKFYCRCIAIATP---TLTWSHNNIELRQSV 8356
            |:..:|.|....:..|:..|:  ||.....||.||...|. ::.:.|   |::|..:...|::..
Human   227 KFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCE-VSSSNPEYTTVSWLKDGTSLKKQN 290

  Fly  8357 KFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYG-SREEVVFLNVQPLPKEQPRYRTESTPVRR 8420
            .|...         :..|..|..|:|..:..|..| .|.|.|||.||..|:
Human   291 TFTLN---------LREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPE-------------- 332

  Fly  8421 REPLPYTFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKPVP-NVRWYKDGRELSKYEYAM 8484
                            ||...:|....::.... :.||.....|:| |..||.:|:|:.......
Human   333 ----------------PSTVQILHSPAVEGSQV-EFLCMSLANPLPTNYTWYHNGKEMQGRTEEK 380

  Fly  8485 THSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEGEWVTPEQAQLAHNFLYSGDRKY 8549
            .|...::        |..:|.|||.|.|..||.:......::.::...:...:..|
Human   381 VHIPKIL--------PWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQN--------- 428

  Fly  8550 IEQPIKPAPLPIVTSRQYTSSSVQNTSEP-------------QGDKVNVSNSNSSGISNK--KKY 8599
                    |:||......|.|...|:|.|             :...:.|....:.|..|.  ...
Human   429 --------PMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACA 485

  Fly  8600 ASNSLQAPGSPSRSRSATKELILPPDDSLMCKPEFTKPLHDLTIHDGEQLILTC-YVKGDP-EPQ 8662
            |.||..:..||     ....:...|.|..:.|   .|||.:  ||.|..:.|.| :....| |.|
Human   486 ACNSWCSWASP-----VALNVQYAPRDVRVRK---IKPLSE--IHSGNSVSLQCDFSSSHPKEVQ 540

  Fly  8663 ISWSKNGKSLSSSDILDLRYKNGIATLTINEVFPEDEGVITCTATNSVGAVETKCKLTIQPLDKN 8727
            ..|.|||:.|...           :.|..:.:.|||.|..:|...||:|...:|. .|::.|...
Human   541 FFWEKNGRLLGKE-----------SQLNFDSISPEDAGSYSCWVNNSIGQTASKA-WTLEVLYAP 593

  Fly  8728 INKR-KVNAGDNAPKIVSHLESRFVRDGDAVNLACRIIG---AQHFDVVWLHNNKEIKPSKDFQY 8788
            ...| .::.||.            |.:|.:..|.|....   ..|:  .|            |.:
Human   594 RRLRVSMSPGDQ------------VMEGKSATLTCESDANPPVSHY--TW------------FDW 632

  Fly  8789 TNEANIY---RLQIAEIFPEDGGTYTCEAFNDIGES---FSTCTI 8827
            .|::..|   :|::..:..:..|.|.|:..|.:|:.   .||.|:
Human   633 NNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTV 677

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.