DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and MYOM2

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_003961.3 Gene:MYOM2 / 9172 HGNCID:7614 Length:1465 Species:Homo sapiens


Alignment Length:1831 Identity:368/1831 - (20%)
Similarity:584/1831 - (31%) Gaps:672/1831 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  5594 IEASPRPLITWLYNGKEIGSNSRGESGLFQNEL-----TFEIVSSLRSDEGRYTLILKNEHGSFD 5653
            ::..|.|::.|..:|..|  ....|.|.::.|.     |.||..:...|...|:.:..|.||...
Human   177 VQGFPTPVVQWYKDGSLI--CQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVS 239

  Fly  5654 ASAHATVLDR----PSP------PKG-PL---------DI-------TKITRDGCHLTWN----- 5686
            .:| |.|:.|    ..|      |.| ||         |:       ....|:|..:|..     
Human   240 TNA-AVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLV 303

  Fly  5687 VPDDDGGSPILHYIIEKMDLSRSTWS-------DAGMS-THIVHD-----VTRLVHR------KE 5732
            .||.....|...:..:.:.|..|.|:       .|.:| :|:..|     ..|:|.|      ..
Human   304 TPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSA 368

  Fly  5733 YLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPI---ITDWDRDHIDLQWAVPKSDGGAP 5794
            :||       :.::|||..             .|||.|:   ..|.:||::.:.|..|.:...:|
Human   369 FLF-------VRDADPLVT-------------GAPGAPMDLQCHDANRDYVIVTWKPPNTTTESP 413

  Fly  5795 ISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAK 5859
            :..|.:.:.|.|:..|......|.......:..|.||:.|.|||.|||.||.|.||..||.:.| 
Human   414 VMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAA- 477

  Fly  5860 PRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHT 5924
                    :.||:..|::.       :|..||                                 
Human   478 --------LDPLDLRRLQA-------VHLEGE--------------------------------- 494

  Fly  5925 VNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSE 5989
                 .:..||...|       ||..::     ||||.| :...||:.|.|.:||:||...|...
Human   495 -----KEIAIYQDDL-------EGDAQV-----PGPPTG-VHASEISRNYVVLSWEPPTPRGKDP 541

  Fly  5990 ISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVV 6054
            : .|.||| .:...|.|.......:.:.....|..|:||..|..||::.|..|.|:|.....|:.
Human   542 L-MYFIEK-SVVGSGSWQRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQ 604

  Fly  6055 AKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTA 6119
            |:....||.|||:...:.:.|..:.::|.:|  .....::||.::.....|..|...|.:|:...
Human   605 AQDVTVVPSAPGRVLASRNTKTSVVVQWDRP--KHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYN 667

  Fly  6120 EYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGEPVN 6184
            .:....:|:..||.:|:.||||.|..:.|:.|.:                     |||:|.    
Human   668 RFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDV---------------------IKVQAA---- 707

  Fly  6185 LNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTA 6249
            |.:|                                            |..|.:|..|       
Human   708 LTVP--------------------------------------------SHPYGITLLN------- 721

  Fly  6250 DIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPVPGTCP 6314
                                               .||                           
Human   722 -----------------------------------CDG--------------------------- 724

  Fly  6315 NTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANLEW 6379
                                                                      :|..|.|
Human   725 ----------------------------------------------------------HSMTLGW 731

  Fly  6380 HPPDDCGGKPITGYIVERRE-RGGEWIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHP 6443
            ..|...||.||.||.:::|| ....|.:.|:.|:..|..||..|.:|:.|||::.|||.||.|.|
Human   732 KVPKFSGGSPILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEP 796

  Fly  6444 SKPSDPMTAEHQRYRPDPPEP-PKPD----RITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGK 6503
            |.||:....|....    ||| |..|    .:....:.:.|:.|...|.|.:.||:|:.|.::..
Human   797 SDPSEHFKCEAWTM----PEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAG 857

  Fly  6504 DWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMELGKVR 6568
            :|.|||.....|....|..|::|:.|.|||.|.|..|...||..|:|:.:|.:|.        .:
Human   858 EWITVNQTTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPG--------TK 914

  Fly  6569 DIVCRAGDDFSIHVPYLAF-----PKPNAF-WYSNDNMLDDNNRVHKHLTDDAASVVVKNSKRAD 6627
            :|  .||.|...:: ||.|     ...:.| |..:...:.|:.|.......|.:.:.:||..:.|
Human   915 EI--SAGVDEQGNI-YLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKED 976

  Fly  6628 SGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRA--DEFSGDSLTLYWNPPNDDGGSAIQNYII 6690
            .|.|.:.:.:|.|..::.    ||| |....||.|  :|....::.|         .|.:...|.
Human   977 LGTYSVSVSDTDGVSSSF----VLD-PEELERLMALSNEIKNPTIPL---------KSELAYEIF 1027

  Fly  6691 EKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHPFDIPN 6755
            :|...|  .|           ::..:|..:..|.| :|.:.:...|:          .|......
Human  1028 DKGRVR--FW-----------LQAEHLSPDASYRF-IINDREVSDSE----------IHRIKCDK 1068

  Fly  6756 TPGIPHGIDSTEDSITI----AWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIP 6816
            ..||   |:...|..:|    .:|...|||.:.....::   |:.|                ...
Human  1069 ATGI---IEMVMDRFSIENEGTYTVQIHDGKAKSQSSLV---LIGD----------------AFK 1111

  Fly  6817 NLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRP-PHAPK-----ITSDLSIRDMTVIAGDE-- 6873
            .::|.||::.:.                  |.|:. ||..:     :|.:..:|.:..:|..:  
Human  1112 TVLEEAEFQRKE------------------FLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKE 1158

  Fly  6874 -----FRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTN 6933
                 .:..|.|.....|.....:..| :||                 |.:|:|. |.|..||.:
Human  1159 TVFKWLKDDVLYETETLPNLERGICEL-LIP-----------------KLSKKDH-GEYKATLKD 1204

  Fly  6934 NKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLDNSGSWVK 6998
            ::|.|     |::::                    :|.|.                         
Human  1205 DRGQD-----VSILE--------------------IAGKV------------------------- 1219

  Fly  6999 ISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDS 7063
                     ||.|.|...     ||..::    :.||.::         ..|:            
Human  1220 ---------YDDMILAMS-----RVCGKS----ASPLKVL---------CTPE------------ 1245

  Fly  7064 GNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKN 7128
                          |.|:|.:...:.|.:.      .::..||.|      |:.||: .||....
Human  1246 --------------GIRLQCFMKYFTDEMK------VNWCHKDAK------ISSSEH-MRIGGSE 1283

  Fly  7129 AAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIG 7193
            .....:...|:  .|.|||:|.....|                    :|...|       ..|:.
Human  1284 EMAWLQICEPT--EKDKGKYTFEIFDG--------------------KDNHQR-------SLDLS 1319

  Fly  7194 GAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWIT 7258
            |         ...|..:.     |...::...||..:.||              ::|| .||.:|
Human  1320 G---------QAFDEAFA-----EFQQFKAAAFAEKNRGR--------------LIGG-LPDVVT 1355

  Fly  7259 RLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDG 7323
            .::      ||...|.|...|.|.|...|.:|.::||::........:.....:.|..|.:.|.|
Human  1356 IME------GKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSG 1414

  Fly  7324 DYTCEAMNSLG 7334
            .|:....|..|
Human  1415 KYSINIKNKYG 1425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845 16/64 (25%)
I-set 5570..5660 CDD:254352 18/70 (26%)
FN3 5664..5755 CDD:238020 27/137 (20%)
FN3 5764..5853 CDD:238020 30/91 (33%)
I-set 5865..5954 CDD:254352 11/88 (13%)
Ig 5882..5954 CDD:299845 8/71 (11%)
FN3 5958..6049 CDD:238020 31/90 (34%)
FN3 6062..6153 CDD:238020 24/90 (27%)
I-set 6173..6255 CDD:254352 10/81 (12%)
Ig_Titin_like 6182..6255 CDD:143225 6/72 (8%)
FN3 6259..6350 CDD:238020 2/90 (2%)
FN3 6359..6451 CDD:238020 33/92 (36%)
FN3 6470..6552 CDD:238020 27/81 (33%)
I-set 6564..6650 CDD:254352 19/91 (21%)
Ig_Titin_like 6577..6650 CDD:143225 16/78 (21%)
FN3 6654..6745 CDD:238020 16/92 (17%)
FN3 6754..6840 CDD:238020 14/89 (16%)
I-set 6855..6946 CDD:254352 19/102 (19%)
Ig 6874..6946 CDD:299845 16/71 (23%)
FN3 6950..7042 CDD:238020 10/91 (11%)
FN3 7050..7139 CDD:238020 13/88 (15%)
FN3 7151..7237 CDD:238020 11/85 (13%)
I-set 7254..7334 CDD:254352 20/79 (25%)
Ig 7272..7339 CDD:143165 16/63 (25%)
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
MYOM2NP_003961.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..61
I-set 154..246 CDD:254352 18/71 (25%)
Ig 171..242 CDD:143165 16/66 (24%)
IG_like 290..372 CDD:214653 18/88 (20%)
IGc2 291..354 CDD:197706 12/62 (19%)
FN3 383..475 CDD:238020 31/91 (34%)
FN3 511..603 CDD:238020 31/94 (33%)
FN3 612..702 CDD:238020 24/112 (21%)
FN3 711..801 CDD:238020 39/260 (15%)
FN3 813..903 CDD:238020 28/89 (31%)
IG_like <940..995 CDD:214653 12/58 (21%)
Ig <942..995 CDD:299845 11/56 (20%)
Ig_M-protein_C 1344..1435 CDD:143299 25/103 (24%)
I-set 1347..1435 CDD:254352 23/86 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1442..1465
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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