DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and MAP3K6

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_004663.3	Gene:	MAP3K6 / 9064	HGNCID:	6858	Length:	1288	Species:	Homo sapiens

Alignment Length:	732	Identity:	143/732 - (19%)
Similarity:	248/732 - (33%)	Gaps:	231/732 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  7646 SPPLIVKPLRDANCIQNHNA--QFTCTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNIN 7708
            ||.:|:..|.....:|:::|  :...|:..:|...::                    :.|.:..:
Human   273 SPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVA--------------------EQHNVCFH 317

  Fly  7709 DVFGEDADEYVCRAVNKAGAKSTRATLAIMTAPKL----NVPP-------RFRDTAYFDKGENVV 7762
            ..|          |:|:......||....:..|.:    :|.|       |.....:|..|
Human   318 YTF----------ALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSG---- 368

  Fly  7763 IKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAVLIIRDGSHL-DSGPYRITAENELG--- 7823
              ....|..:...||.|...::|...|..:..    |||:|..|.|. ||...|:.. .:||
Human   369 --FQDAGHREQAYHWYRKAFDVEPSLHSGINA----AVLLIAAGQHFEDSKELRLIG-MKLGCLL 426

  Fly  7824 ---------------------------------------------------SDTAIIQVQISDRP 7837
                                                               .:|.::.......|
Human   427 ARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTP 491

  Fly  7838 DPPRFP----------LIESI---------GTESLSL-----------SWKAPVWDGCSDITNYY 7872
            :||..|          |::|.         |.:.|.|           ..:....|..|.:|...
Human   492 EPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSL 556

  Fly  7873 VERREHPL-SSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTST----------- 7925
            :|.....: |||      .|...::.|::..|..:...|   :|....|.|...
Human   557 LEPETQDIPSSW------TFPVASICGVSASKRDERCCF---LYALPPAQDVQLCFPSVGHCQWF 612

  Fly  7926 --LIKTKESVKKKPIERKWEIDANGRKLRGKADGPVK----DYDSYVFDIYSKFVPQPVEISQQS 7984
              ||:.            |..:.:......:|:|..:    ||:      |:       |..::.
Human   613 CGLIQA------------WVTNPDSTAPAEEAEGAGEMLEFDYE------YT-------ETGERL 652

  Fly  7985 VYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINL 8049
            |         :|.|.:|||:..|:|.|....|.|.||...|.....:..||.:..:|.|:.::..
Human   653 V---------LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRY 708

  Fly  8050 HDAFEDDDEMILILEFLSGGELFERITAEGYVM--TEAEVINYMRQICEGIRHMHEQNIIHLDIK 8112
            ..:......:.:.:|.:.||.|...:.:....:  .|:.:..|.|||.:|:.::|:.:|:|.|||
Human   709 LGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773

  Fly  8113 PENIMCQTRSSTNVKLIDFGLATRLDPNEVVKIT------TGTAEFAAPEIVNREPVGF--YTDM 8169
            .:|::..|.|.. :|:.|||.:.||     ..||      |||.::.||||:::.|.|:  ..|:
Human   774 GDNVLINTFSGL-LKISDFGTSKRL-----AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADI 832

  Fly  8170 WATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKY-------ISEEAKDFIRKLLVR 8227
            |:.|.....:.:|..||......|...        |.|..:|.       :|.||:.|:.:....
Human   833 WSLGCTVIEMATGRPPFHELGSPQAAM--------FQVGMYKVHPPMPSSLSAEAQAFLLRTFEP 889

  Fly  8228 NKEKRMTAHECLLHPWL 8244
            :...|.:|...|..|:|
Human   890 DPRLRASAQTLLGDPFL 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352	12/90 (13%)
Ig	7665..7734	CDD:143165	8/70 (11%)
Ig	7760..7833	CDD:299845	18/127 (14%)
FN3	7837..7927	CDD:238020	23/133 (17%)
STKc_Twitchin_like	7986..8244	CDD:271016	71/274 (26%)
S_TKc	7989..8244	CDD:214567	71/271 (26%)
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
MAP3K6	NP_004663.3	DUF4071	129..506	CDD:290020	42/273 (15%)
		STKc_ASK	639..906	CDD:270794	76/302 (25%)
		S_TKc	653..906	CDD:214567	72/275 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..997		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1123..1157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910